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{{Infobox enzyme
| Name = 23S rRNA pseudouridine<sup>955/2504/2580</sup> synthase
| EC_number = 5.4.99.24
| CAS_number = 
| IUBMB_EC_number = 5/4/99/24
| GO_code = 
| image = 
| width = 
| caption =
}}
'''23S rRNA pseudouridine<sup>955/2504/2580</sup> synthase''' ({{EC number|5.4.99.24}}, ''RluC'', ''pseudouridine synthase RluC'') is an [[enzyme]] with system name ''23S rRNA-uridine<sup>955/2504/2580</sup> uracil mutase''.<ref>{{cite journal | title = Identification of novel <em>Escherichia coli</em> ribosome-associated proteins using isobaric tags and multidimensional protein identification  techniques |author = Jiang, M., Sullivan, S.M., Walker, A.K., Strahler, J.R., Andrews, P.C. and Maddock, J.R. |journal = J. Bacteriol. |year = 2007 |volume = 189 |pages = 3434–3444 |pmid = 17337586}}</ref><ref>{{cite journal | title = The <em>rluC</em> gene of <em>Escherichia coli</em> codes for a pseudouridine synthase that is solely responsible for synthesis of pseudouridine at positions 955,  2504, and 2580 in 23 S ribosomal RNA |author = Conrad, J., Sun, D., Englund, N. and Ofengand, J. |journal = J. Biol. Chem. |year = 1998 |volume = 273 |pages = 18562–18566 |pmid = 9660827}}</ref><ref>{{cite journal | title = Crystallization and characterization of a fragment of pseudouridine synthase RluC from <em>Escherichia coli</em> |author = Corollo, D., Blair-Johnson, M., Conrad, J., Fiedler, T., Sun, D., Wang, L., Ofengand, J. and Fenna, R. |journal = Acta Crystallogr. D Biol. Crystallogr. |year = 1999 |volume = 55 |pages = 302–304 |pmid = 10089432}}</ref><ref>{{cite journal | title = An indigenous posttranscriptional modification in the ribosomal peptidyl transferase center confers resistance to an array of protein synthesis  inhibitors |author = Toh, S.M. and Mankin, A.S. |journal = J. Mol. Biol. |year = 2008 |volume = 380 |pages = 593–597 |pmid = 18554609}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: 23S rRNA [[uridine]]<sup>955</sup>/uridine<sup>2504</sup>/uridine<sup>2580</sup> <math>\rightleftharpoons</math> 23S rRNA pseudouridine<sup>955</sup>/pseudouridine<sup>2504</sup>/pseudouridine<sup>2580</sup>

The enzyme converts uridines at position 955, 2504 and 2580 of 23S rRNA to pseudouridines.

== References ==
{{reflist}}

== External links ==
* {{MeshName|23S+rRNA+pseudouridine955/2504/2580+synthase}}

[[Category:EC 5.4.99]]