View source for Glycerol-3-phosphate cytidylyltransferase

{{enzyme
| Name = holo-citrate lyase synthase
| EC_number = 2.7.7.61
| CAS_number = 312492-44-7
| IUBMB_EC_number = 2/7/7/61
| GO_code = 0050519
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''holo-ACP synthase''' ({{EC number|2.7.7.61}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:2'-(5"-triphosphoribosyl)-3'-dephospho-CoA + apo-citrate lyase <math>\rightleftharpoons</math> holo-citrate lyase + diphosphate

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[2'-(5''-triphosphoribosyl)-3'-dephospho-CoA]] and [[apo-citrate lyase]], whereas its two [[product (chemistry)|products]] are [[holo-citrate lyase]] and [[diphosphate]].

This enzyme belongs to the family of [[transferase]]s, specifically those transferring phosphorus-containing [[nucleotide]] groups ([[nucleotidyltransferase]]s).  The systematic name of this enzyme class is '''2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase adenylyltransferase'''. Other names in common use include '''2'-(5"-phosphoribosyl)-3'-dephospho-CoA transferase''', '''2'-(5"-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase''', and '''CitX'''.  This enzyme participates in [[two-component system - general]].  

==Structural studies==

As of late 2007, only one [[tertiary structure|structure]] has been solved for this class of enzymes, with the [[Protein Data Bank|PDB]] accession code {{PDB link|2BDD}}.

==References==
{{reflist|1}}
* {{cite journal | author = Schneider K, Dimroth P, Bott M | date = 2000 | title = Biosynthesis of the prosthetic group of citrate lyase | journal = Biochemistry.  | volume = 39 | pages = 9438&ndash;50  | pmid = 10924139 | doi = 10.1021/bi000401r | issue = 31 }}
* {{cite journal | author = Schneider K, Dimroth P, Bott M | date = 2000 | title = Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group | journal = FEBS. Lett.  | volume = 483 | pages = 165&ndash;8  | pmid = 11042274 | doi = 10.1016/S0014-5793(00)02105-0 | issue = 2-3 }}

{{enzyme-stub}}

[[Category:EC 2.7.7]]
[[Category:Enzymes of known structure]]