View source for Indole-3-carboxylate decarboxylase

{{Infobox enzyme
| Name = 6-carboxytetrahydropterin synthase
| EC_number = 4.1.2.50
| CAS_number = 
| IUBMB_EC_number = 4/1/2/50
| GO_code = 
| image = 
| width = 
| caption =
}}
'''6-carboxytetrahydropterin synthase''' ({{EC number|4.1.2.50}}, ''CPH4 synthase'', ''queD (gene)'', ''ToyB'', ''ykvK (gene)'') is an [[enzyme]] with system name ''7,8-dihydroneopterin 3'-triphosphate acetaldehyde-lyase (6-carboxy-5,6,7,8-tetrahydropterin and triphosphate-forming)''.<ref>{{cite journal | title = Crystallization and preliminary X-ray characterization of <em>queD</em> from <em>Bacillus subtilis</em>, an enzyme involved in queuosine biosynthesis |author = Cicmil, N. and Shi, L. |journal = Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. |date = 2008 |volume = 64 |pages = 119-122 |pmid = 18259064}}</ref><ref>{{cite journal | title = <em>Escherichia coli</em> QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase |author = McCarty, R.M., Somogyi, A. and Bandarian, V. |journal = Biochemistry |date = 2009 |volume = 48 |pages = 2301-2303 |pmid = 19231875}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: 7,8-dihydroneopterin 3'-triphosphate + H<sub>2</sub>O <math>\rightleftharpoons</math> 6-carboxy-5,6,7,8-tetrahydropterin + [[acetaldehyde]] + [[triphosphate]]

This enzyme binds Zn<sup>2+</sup>. 

== References ==
{{reflist}}

== External links ==
* {{MeshName|6-carboxytetrahydropterin+synthase}}

[[Category:EC 4.1.2]]