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{{Infobox enzyme
| Name = Protein-fructosamine 3-kinase
| EC_number = 2.7.1.171
| CAS_number = 
| IUBMB_EC_number = 2/7/1/171
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Protein-fructosamine 3-kinase''' ({{EC number|2.7.1.171}}, ''[[Fructosamine-3-kinase|FN3K]]'', ''fructosamine 3-kinase'') is an [[enzyme]] with system name ''ATP:(protein)-N<sup>6</sup>-D-fructosyl-L-lysine 3-phosphotransferase''.<ref>{{cite journal | title = Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity ''in vivo'' |author = Szwergold, B.S., Howell, S. and Beisswenger, P.J. |journal = Diabetes |year = 2001 |volume = 50 |pages = 2139–2147 |pmid = 11522682 |doi=10.2337/diabetes.50.9.2139}}</ref><ref>{{cite journal | title = Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase |author = Delpierre, G., Rider, M.H., Collard, F., Stroobant, V., Vanstapel, F., Santos, H. and Van Schaftingen, E. |journal = Diabetes |year = 2000 |volume = 49 |pages = 1627–1634 |pmid = 11016445 |doi=10.2337/diabetes.49.10.1627}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: ATP + [protein]-N<sup>6</sup>-D-fructosyl-L-lysine <math>\rightleftharpoons</math> ADP + [protein]-N<sup>6</sup>-(3-O-phospho-D-fructosyl)-L-lysine

Nonenzymatic [[glycation]] is a factor in the [[pathogenesis]] of [[diabetes]].

== References ==
{{reflist}}

== External links ==
* {{MeshName|Protein-fructosamine+3-kinase}}

[[Category:EC 2.7.1]]