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<p>index updated</p> <p><b>New page</b></p><div>{{Infobox enzyme<br /> | Name = D-alanine—(R)-lactate ligase<br /> | EC_number = 6.1.2.1<br /> | CAS_number = <br /> | IUBMB_EC_number = 6/1/2/1<br /> | GO_code = <br /> | image = <br /> | width = <br /> | caption =<br /> }}<br /> &#039;&#039;&#039;D-alanine—(R)-lactate ligase&#039;&#039;&#039; ({{EC number|6.1.2.1}}, &#039;&#039;VanA&#039;&#039;, &#039;&#039;VanB&#039;&#039;, &#039;&#039;VanD&#039;&#039;) is an [[enzyme]] with system name &#039;&#039;D-alanine:(R)-lactate ligase (ADP-forming)&#039;&#039;.&lt;ref&gt;{{cite journal | title = Molecular basis for vancomycin resistance in &#039;&#039;Enterococcus faecium&#039;&#039; BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA |author = Bugg, T.D., Wright, G.D., Dutka-Malen, S., Arthur, M., Courvalin, P. and Walsh, C.T. |journal = Biochemistry |year = 1991 |volume = 30 |pages = 10408–10415 |pmid = 1931965}}&lt;/ref&gt;&lt;ref&gt;{{cite journal | title = Purification and characterization of the VanB ligase associated with type B vancomycin resistance in &#039;&#039;Enterococcus faecalis&#039;&#039; V583 |author = Meziane-Cherif, D., Badet-Denisot, M.A., Evers, S., Courvalin, P. and Badet, B. |journal = FEBS Lett. |year = 1994 |volume = 354 |pages = 140–142 |pmid = 7957913}}&lt;/ref&gt;&lt;ref&gt;{{cite journal | title = VanD-type glycopeptide-resistant &#039;&#039;Enterococcus faecium&#039;&#039; BM4339 |author = Perichon, B., Reynolds, P. and Courvalin, P. |journal = Antimicrob. Agents Chemother. |year = 1997 |volume = 41 |pages = 2016–2018 |pmid = 9303405}}&lt;/ref&gt; This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]<br /> <br /> : D-[[alanine]] + (R)-[[Lactic acid|lactate]] + ATP &lt;math&gt;\rightleftharpoons&lt;/math&gt; D-alanyl-(R)-lactate + ADP + [[phosphate]]<br /> <br /> The product of this enzyme can be incorporated into the [[peptidoglycan pentapeptide]] instead of the usual D-alanyl-D-alanine dipeptide.<br /> <br /> == References ==<br /> {{reflist}}<br /> <br /> == External links ==<br /> * {{MeshName|D-alanine---(R)-lactate+ligase}}<br /> <br /> {{DEFAULTSORT:D-alanine-(R)-lactate ligase}}<br /> [[Category:EC 6.1.2]]</div>

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