174.53.163.119 at 05:54, 26 December 2012

2012-12-26T05:54:30Z

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{{Infobox enzyme
| Name = Diacetyl reductase, (R)-acetoin forming
| EC_number = 1.1.1.303
| CAS_number =
| IUBMB_EC_number = 1/1/1/303
| GO_code =
| image =
| width =
| caption =
}}
'''Diacetyl reductase ((R)-acetoin forming)''' ({{EC number|1.1.1.303}}, ''(R)-acetoin dehydrogenase'') is an [[enzyme]] with system name ''(R)-acetoin:NAD+ oxidoreductase''.<ref>{{cite journal | title = Purification and characterization of a (R)-2,3-butanediol dehydrogenase from Saccharomyces cerevisiae |author = Heidlas, J. and Tressl, R. |journal = Arch. Microbiol. |year = 1990 |volume = 154 |pages = 267–273 |pmid = 2222122 |issue=3}}</ref><ref>{{cite journal | title = Characterization of a (2R,3R)-2,3-butanediol dehydrogenase as the Saccharomyces cerevisiae YAL060W gene product. Disruption and induction of the gene |author = Gonzalez, E., Fernandez, M.R., Larroy, C., Sola, L., Pericas, M.A., Pares, X. and Biosca, J.A. |journal = J. Biol. Chem. |year = 2000 |volume = 275 |pages = 35876–35885 |pmid = 10938079 |doi=10.1074/jbc.M003035200}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: (R)-acetoin + NAD+ <math>\rightleftharpoons</math> diacetyl + NADH + H+

The reaction is catalysed in the reverse direction. This activity is usually associated with butanediol dehydrogenase activity (EC 1.1.1.4 or EC 1.1.1.76). While the butanediol dehydrogenase activity is reversible, diacetyl reductase activity is irreversible. This enzyme has been reported in the [[yeast]] [[Saccharomyces cerevisiae]]. This enzyme is different from EC 1.1.1.304, [[diacetyl reductase ((S)-acetoin forming)]].

== References ==
{{reflist}}

[[Category:EC 1.1.1]]

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174.53.163.119 at 05:54, 26 December 2012