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2014-01-23T13:59:36Z

Robot - Speedily moving category Accountancy to Category:Accounting per CFDS.

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{{Infobox enzyme
| Name = 25-hydroxycholesterol 7alpha-hydroxylase
| EC_number = 1.14.13.100
| CAS_number =
| IUBMB_EC_number = 1/14/13/100
| GO_code =
| image =
| width =
| caption =
}}
'''25-hydroxycholesterol 7alpha-hydroxylase''' ({{EC number|1.14.13.100}}, ''25-hydroxycholesterol 7alpha-monooxygenase'', ''[[CYP7B1]]'', ''CYP7B1 oxysterol 7alpha-hydroxylase'') is an [[enzyme]] with system name ''cholest-5-ene-3beta,25-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)''.<ref>{{cite journal | title = 7α hydroxylation of 25-hydroxycholesterol in liver microsomes. Evidence that the enzyme involved is different from cholesterol 7α-hydroxylase |author = Toll, A., Wikvall, K., Sudjana-Sugiaman, E., Kondo, K.H. and Björkhem, I. |journal = Eur. J. Biochem. |year = 1994 |volume = 224 |pages = 309–316 |pmid = 7925343}}</ref><ref>{{cite journal | title = Expression cloning of an oxysterol 7α-hydroxylase selective for 24-hydroxycholesterol |author = Li-Hawkins, J., Lund, E.G., Bronson, A.D. and Russell, D.W. |journal = J. Biol. Chem. |year = 2000 |volume = 275 |pages = 16543–16549 |pmid = 10748047 |doi=10.1074/jbc.M001810200}}</ref><ref>{{cite journal | title = Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in the rat |author = Ren, S., Marques, D., Redford, K., Hylemon, P.B., Gil, G., Vlahcevic, Z.R. and Pandak, W.M. |journal = Metabolism |year = 2003 |volume = 52 |pages = 636–642 |pmid = 12759897 |doi=10.1053/meta.2003.50106}}</ref><ref>{{cite journal | title = The enzymes, regulation, and genetics of bile acid synthesis |author = Russell, D.W. |journal = Annu. Rev. Biochem. |year = 2003 |volume = 72 |pages = 137–174 |pmid = 12543708 |doi=10.1146/annurev.biochem.72.121801.161712}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: (1) cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 <math>\rightleftharpoons</math> cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O
: (2) cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 <math>\rightleftharpoons</math> cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O

25-hydroxycholesterol 7α-hydroxylase is a heme-thiolate protein (P-450).

== References ==
{{reflist}}

== External links ==
* {{MeshName|25-hydroxycholesterol+7alpha-hydroxylase}}

[[Category:EC 1.14.13]]

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en>Cydebot: Robot - Speedily moving category Accountancy to :Category:Accounting per CFDS.