Simple magic cube - Revision history

en>The Original Filfi: Link magic square and remove from dusty.

2014-02-20T07:05:09Z

Link magic square and remove from dusty.

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	~~{{enzyme~~		Ed is what individuals call me and my wife doesn't like it at all. I am really fond of to go to karaoke but I've been using on new things recently. Ohio is exactly where her home is. Distributing manufacturing is online psychic chat [[http://appin.co.kr/board_Zqtv22/688025 mouse click the up coming web site]] exactly where my primary income comes from and it's something I really enjoy.<br><br>Here is my blog: online [http://bigpolis.com/blogs/post/6503 good psychic] reading ([http://clothingcarearchworth.com/index.php?document_srl=441551&mid=customer_review clothingcarearchworth.com])
	~~\| Name = NAD<sup>+</sup> kinase~~
	~~\| EC_number = 2~~.~~7.1.23~~
	~~\| CAS_number = 9032-66-0~~
	~~\| IUBMB_EC_number = 2/7/1/23~~
	~~\| GO_code = 0003951~~
	~~\| image = NADK.png~~
	~~\| width =~~
	~~\| caption = Ribbon diagram~~ of NAD<sup>+</sup> kinase in complex with substrates.<ref name="pmid16242716">{{PDB\|1SUW}}; {{cite journal \| author = Liu J, Lou Y, Yokota H, Adams PD, Kim R, Kim SH \| title = Crystal structures of an NAD kinase from Archaeoglobus fulgidus in complex with ATP, NAD, or NADP \| journal = J. Mol. Biol. \| volume = 354 \| issue = 2 \| pages = 289–303 \|date=November 2005 \| pmid = 16242716 \| doi = 10.1016/j.jmb.2005.09.026 \| url = }}</ref>
	}}
	~~{{PBB\|geneid=65220}}~~

	'~~''NAD<sup>+</sup> kinase''' (EC 2~~.7.~~1.23, NADK)~~ is ~~an enzyme that converts~~ [[~~nicotinamide adenine dinucleotide]] (NAD<sup>+<~~/~~sup>) into NADP<sup>+<~~/~~sup>, through phosphorylating the NAD<sup>+</sup> [[coenzyme]]~~.<ref>{{cite journal \|author=Magni G, Orsomando G, Raffaelli N \|title=Structural and functional properties of NAD kinase, a key enzyme in NADP biosynthesis \|journal=Mini reviews in medicinal chemistry \|volume=6 \|issue=7 \|pages=739–46 \|year=2006 \|pmid=16842123 \|doi=10.~~2174~~/~~138955706777698688}}<~~/~~ref> NADP<sup>+</sup> is an essential coenzyme in [[metabolism~~]] and provides reducing power to biosynthetic processes such as [[fatty acid biosynthesis]].<ref>{{cite journal \|author=Pollak N, Dölle C, Ziegler M \|title=The power to reduce: pyridine nucleotides – small molecules with a multitude of functions \|journal=Biochem. J. \|volume=402 \|issue=2 \|pages=205–18 \|year=2007 \|pmid=17295611 \|doi=10.1042/BJ20061638 \|pmc=1798440}}</ref> The structure of the NADK from the [[archaea]]n ''~~[[Archaeoglobus\|Archaeoglobus fulgidus]]'' has been determined~~.<~~ref name="pmid16242716"/~~>

	~~In humans, NAD~~<~~sup~~>~~+</sup> kinase~~ is ~~encoded by the ''NADK''~~ [[gene]].<ref name="pmid11594753">{{cite journal \| author = Lerner F, Niere M, Ludwig A, Ziegler M \| title = Structural and functional characterization of human NAD kinase \| journal = Biochem. Biophys. Res. Commun. \| volume = 288 \| issue = 1 \| pages = 69–74 \|date=October 2001 \| pmid = 11594753 \| doi = 10.1006/~~bbrc~~.~~2001.5735 \| url = }}</ref>~~

	~~== Reaction ==~~

	~~[[Adenosine triphosphate\|ATP]] + [[Nicotinamide adenine dinucleotide\|NAD<sup>+<~~/~~sup>]] <math>\rightleftharpoons<~~/~~math> [[Adenosine diphosphate\|ADP]] + [[Nicotinamide adenine dinucleotide phosphate\|NADP<sup>+<~~/~~sup>]]~~

	~~==See also==~~
	*[[Oxidative phosphorylation]]
	*[[Electron transport chain]]
	*[[Metabolism]]

	~~==References==~~
	~~{{reflist}}~~

	~~==Further~~ reading==
	~~{{refbegin \| 2}}~~
	~~{{PBB_Further_reading~~
	~~\| citations =~~
	*{{cite journal \| author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' \|title=A "double adaptor" method for improved shotgun library construction \|journal=Anal. Biochem. \|volume=236 \|issue= 1 \|pages= 107–13 \|year= 1996 \|pmid= 8619474 \|doi= 10.1006/abio.1996.0138 }}
	*{{cite journal \| author=Yu W, Andersson B, Worley KC, ''et al.'' \|title=Large-Scale Concatenation cDNA Sequencing \|journal=Genome Res. \|volume=7 \|issue= 4 \|pages= 353–8 \|year= 1997 \|pmid= 9110174 \|doi= 10.1101/gr.7.4.353\| pmc=139146 }}
	*{{cite journal \| author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' \|title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences \|journal=Proc. Natl. Acad. Sci. U.S.A. \|volume=99 \|issue= 26 \|pages= 16899–903 \|year= 2003 \|pmid= 12477932 \|doi= 10.1073/pnas.242603899 \| pmc=139241 }}
	*{{cite journal \| author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' \|title=Complete sequencing and characterization of 21,243 full-length human cDNAs \|journal=Nat. Genet. \|volume=36 \|issue= 1 \|pages= 40–5 \|year= 2004 \|pmid= 14702039 \|doi= 10.1038/ng1285 }}
	*{{cite journal \| author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' \|title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (~~MGC) \|journal=Genome Res. \|volume=14 \|issue= 10B \|pages= 2121–7 \|year= 2004 \|pmid= 15489334 \|doi= 10.1101/gr.2596504 \| pmc=528928 }}~~
	*{{cite journal \| author=Stelzl U, Worm U, Lalowski M, ''et al.'' \|title=A human protein-protein interaction network: a resource for annotating the proteome \|journal=Cell \|volume=122 \|issue= 6 \|pages= 957–68 \|year= 2005 \|pmid= 16169070 \|doi= 10.1016/j.cell.2005.08.029 }}
	*{{cite journal \| author=Rual JF, Venkatesan K, Hao T, ''et al.'' \|title=Towards a proteome-scale map of the human protein-protein interaction network \|journal=Nature \|volume=437 \|issue= 7062 \|pages= 1173–8 \|year= 2005 \|pmid= 16189514 \|doi= 10.1038/nature04209 }}
	*{{cite journal \| author=Gregory SG, Barlow KF, McLay KE, ''et al.'' \|title=The DNA sequence and biological annotation of human chromosome 1 \|journal=Nature \|volume=441 \|issue= 7091 \|pages= 315–21 \|year= 2006 \|pmid= 16710414 \|doi= 10.1038/nature04727 }}
	*{{cite journal \| author=Ewing RM, Chu P, Elisma F, ''et al.'' \|title=Large-scale mapping of human protein–protein interactions by mass spectrometry \|journal=Mol. Syst. Biol. \|volume=3 \|issue= 1\|pages= 89 \|year= 2007 \|pmid= 17353931 \|doi= 10.1038/msb4100134 \| pmc=1847948 }}
	*{{cite journal \| author=Pollak N, Niere M, Ziegler M \|title=NAD kinase levels control the NADPH concentration in human cells \|journal=J. Biol. Chem. \|volume=282 \|issue= 46 \|pages= 33562–71 \|year= 2008 \|pmid= 17855339 \|doi= 10.1074/jbc.M704442200 }}
	}}
	~~{{refend}}~~

	~~==External links==~~
	*[http://au.~~expasy.org~~/~~enzyme/2.7.1.23 ENZYME entry on EC 2.7.1.23]~~
	*[http://www.brenda-enzymes.~~org/~~php~~/result_flat.php4~~?~~ecno~~=2.~~7.1.23 BRENDA entry on EC 2.7.1.23~~]

	~~{{Kinases}}~~

	~~{{DEFAULTSORT:Nad+ Kinase}}~~
	~~[[Category:EC 2.7.1]]~~
	~~[[Category:Cellular respiration]]~~
	~~[[Category:Metabolism]]~~
	~~[[Category:Human proteins]]~~


	~~{{transferase-stub}}~~
	~~{{metabolism-stub}}~~

en>Jaksmata: add image

2008-05-21T19:13:20Z

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{{enzyme
| Name = NAD+ kinase
| EC_number = 2.7.1.23
| CAS_number = 9032-66-0
| IUBMB_EC_number = 2/7/1/23
| GO_code = 0003951
| image = NADK.png
| width =
| caption = Ribbon diagram of NAD+ kinase in complex with substrates.<ref name="pmid16242716">{{PDB|1SUW}}; {{cite journal | author = Liu J, Lou Y, Yokota H, Adams PD, Kim R, Kim SH | title = Crystal structures of an NAD kinase from Archaeoglobus fulgidus in complex with ATP, NAD, or NADP | journal = J. Mol. Biol. | volume = 354 | issue = 2 | pages = 289–303 |date=November 2005 | pmid = 16242716 | doi = 10.1016/j.jmb.2005.09.026 | url = }}</ref>
}}
{{PBB|geneid=65220}}

'''NAD+ kinase''' (EC 2.7.1.23, NADK) is an enzyme that converts [[nicotinamide adenine dinucleotide]] (NAD+) into NADP+, through phosphorylating the NAD+ [[coenzyme]].<ref>{{cite journal |author=Magni G, Orsomando G, Raffaelli N |title=Structural and functional properties of NAD kinase, a key enzyme in NADP biosynthesis |journal=Mini reviews in medicinal chemistry |volume=6 |issue=7 |pages=739–46 |year=2006 |pmid=16842123 |doi=10.2174/138955706777698688}}</ref> NADP+ is an essential coenzyme in [[metabolism]] and provides reducing power to biosynthetic processes such as [[fatty acid biosynthesis]].<ref>{{cite journal |author=Pollak N, Dölle C, Ziegler M |title=The power to reduce: pyridine nucleotides – small molecules with a multitude of functions |journal=Biochem. J. |volume=402 |issue=2 |pages=205–18 |year=2007 |pmid=17295611 |doi=10.1042/BJ20061638 |pmc=1798440}}</ref> The structure of the NADK from the [[archaea]]n ''[[Archaeoglobus|Archaeoglobus fulgidus]]'' has been determined.<ref name="pmid16242716"/>

In humans, NAD+ kinase is encoded by the ''NADK'' [[gene]].<ref name="pmid11594753">{{cite journal | author = Lerner F, Niere M, Ludwig A, Ziegler M | title = Structural and functional characterization of human NAD kinase | journal = Biochem. Biophys. Res. Commun. | volume = 288 | issue = 1 | pages = 69–74 |date=October 2001 | pmid = 11594753 | doi = 10.1006/bbrc.2001.5735 | url = }}</ref>

== Reaction ==

[[Adenosine triphosphate|ATP]] + [[Nicotinamide adenine dinucleotide|NAD+]] <math>\rightleftharpoons</math> [[Adenosine diphosphate|ADP]] + [[Nicotinamide adenine dinucleotide phosphate|NADP+]]

==See also==
*[[Oxidative phosphorylation]]
*[[Electron transport chain]]
*[[Metabolism]]

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-Scale Concatenation cDNA Sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal | author=Pollak N, Niere M, Ziegler M |title=NAD kinase levels control the NADPH concentration in human cells |journal=J. Biol. Chem. |volume=282 |issue= 46 |pages= 33562–71 |year= 2008 |pmid= 17855339 |doi= 10.1074/jbc.M704442200 }}
}}
{{refend}}

==External links==
*[http://au.expasy.org/enzyme/2.7.1.23 ENZYME entry on EC 2.7.1.23]
*[http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.7.1.23 BRENDA entry on EC 2.7.1.23]

{{Kinases}}

{{DEFAULTSORT:Nad+ Kinase}}
[[Category:EC 2.7.1]]
[[Category:Cellular respiration]]
[[Category:Metabolism]]
[[Category:Human proteins]]

{{transferase-stub}}
{{metabolism-stub}}