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Library Technician Anton from Strathroy, has many passions that include r/c helicopters, property developers in condo new launch singapore and coin collecting. Finds the beauty in planing a trip to spots around the globe, recently only returning from Old Town of Corfu. A maintenance dose is the maintenance rate [mg/h] of drug administration equal to the rate of elimination at steady state. This is not to be confused with a dose regimen, which is a type of drug therapy in which the dose [mg] of a drug is given at a regular dosing interval on a repetitive basis. Continuing the maintenance dose for about 4 to 5 half lives (t_½) of the drug will approximate the steady state level. One or more doses higher than the maintenance dose can be given together at the beginning of therapy with a loading dose.

A loading dose is most useful for drugs that are eliminated from the body relatively slowly. Such drugs need only a low maintenance dose in order to keep the amount of the drug in the body at the appropriate level, but this also means that, without an initial higher dose, it would take a long time for the amount of the drug in the body to reach that level.

Calculating the maintenance dose

The required maintenance dose may be calculated as:

$\text{MD}=\frac{C_{p}CL}{F}$

Where:

MD	is the maintenance dose rate [mg/h]
Cp	= desired peak concentration of drug [mg/L]
CL	= clearance of drug in body [L/h]
F	= bioavailability

For an intravenously administered drug, the bioavailability F will equal 1, since the drug is directly introduced to the bloodstream. If the patient requires an oral dose, bioavailability will be less than 1 (depending upon absorption, first pass metabolism etc.), requiring a larger loading dose.

See also

• Therapeutic index

References

43 year old Petroleum Engineer Harry from Deep River, usually spends time with hobbies and interests like renting movies, property developers in singapore new condominium and vehicle racing. Constantly enjoys going to destinations like Camino Real de Tierra Adentro.

I'm a 31 years old, married and work at the university (Optometry).
In my free time I learn Danish. I've been twicethere and look forward to returning sometime near future. I like to read, preferably on my ebook reader. I like to watch American Dad and American Dad as well as docus about nature. I love Chess.



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