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{{Pfam box |Symbol = Thymidylate_kin |Name = Thymidylate kinase |Pfam = PF02223 |InterPro = IPR000062 |PROSITE = PDOC01034 |PDB = {{PDB|1e2d}} {{PDB|1e2e}} {{PDB|1e2f}} {{PDB|1e2g}} {{PDB|1e2q}} {{PDB|1e98}} {{PDB|1e99}} {{PDB|1e9a}} {{PDB|1e9b}} {{PDB|1e9c}} }}
 
'''Thymidylate kinase''' ({{EC number|2.7.4.9}}; [[dTMP kinase]]) catalyzes the [[phosphorylation]] of [[Thymidine monophosphate|thymidine 5'-monophosphate]] (dTMP) to form thymidine 5'-diphosphate (dTDP) in the presence of ATP and magnesium:
 
: ATP + thymidine 5'-phosphate <math>\rightleftharpoons</math> ADP + thymidine 5'-diphosphate
 
Thymidylate kinase is a ubiquitous enzyme of about 25 Kd and is important in the dTTP synthesis pathway for DNA synthesis. The function of dTMP kinase in eukaryotes comes from the study of a cell cycle mutant, cdc8, in Saccharomyces cerevisiae ''[[Saccharomyces cerevisiae]]''. Structural and functional analyses suggest that the cDNA codes for authentic human dTMP kinase. The mRNA levels and enzyme activities corresponded to cell cycle progression and cell growth stages.<ref name="PUB00016913">{{cite journal |author=Li C, Huang SH, Tang A, Drisco B, Zhang SQ, Seeger R, Jong A |title=Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth |journal=DNA Cell Biol. |volume=13 |issue=5 |pages=461–471 |year=1994 |pmid=8024690 |doi=10.1089/dna.1994.13.461}}</ref>
 
==Subfamilies==
*[[Predicted thymidylate kinase, TKRP1]] {{InterPro|IPR014505}}
 
==Human proteins containing this domain ==
[[DTYMK]];
 
==See also==
*[[Thymidine kinase]]
*[[Thymidylate synthase]]
 
==References==
{{reflist}}
 
{{InterPro content|IPR000062}}
 
{{DEFAULTSORT:Thymidylate Kinase}}
[[Category:Protein families]]
 
 
{{protein-stub}}

Revision as of 18:42, 11 October 2013

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Thymidylate kinase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.; dTMP kinase) catalyzes the phosphorylation of thymidine 5'-monophosphate (dTMP) to form thymidine 5'-diphosphate (dTDP) in the presence of ATP and magnesium:

ATP + thymidine 5'-phosphate ADP + thymidine 5'-diphosphate

Thymidylate kinase is a ubiquitous enzyme of about 25 Kd and is important in the dTTP synthesis pathway for DNA synthesis. The function of dTMP kinase in eukaryotes comes from the study of a cell cycle mutant, cdc8, in Saccharomyces cerevisiae Saccharomyces cerevisiae. Structural and functional analyses suggest that the cDNA codes for authentic human dTMP kinase. The mRNA levels and enzyme activities corresponded to cell cycle progression and cell growth stages.[1]

Subfamilies

Human proteins containing this domain

DTYMK;

See also

References

43 year old Petroleum Engineer Harry from Deep River, usually spends time with hobbies and interests like renting movies, property developers in singapore new condominium and vehicle racing. Constantly enjoys going to destinations like Camino Real de Tierra Adentro.

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Template:Protein-stub

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