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{{merge from|Defined daily dose|date=January 2012}}
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A '''maintenance dose''' is the maintenance rate [mg/h] of drug administration equal to the rate of elimination at steady state. This is not to be confused with a dose regimen, which is a type of drug therapy in which the [[dosing|dose]] [mg] of a [[drug]] is given at a regular dosing interval on a repetitive basis. Continuing the maintenance dose for about 4 to 5 [[half life|half lives]] (t<sub>½</sub>) of the drug will approximate the [[pharmacokinetics|steady state]] level.<ref>{{cite book |last1= Houglum|first1= Joel |authorlink1= |last2= Harrelson|first2= Gary |title= Principles of Pharmacology for Athletic Trainers|url= http://books.google.com/books?id=wbkoeZuwqjwC|accessdate= 2012-01-26|type= |year= 2010|publisher= SLACK Incorporated|isbn= 1-55642-901-0|page=51}}</ref> One or more doses higher than the maintenance dose can be given together at the beginning of therapy with a [[loading dose]].<ref name="urlCp vs time - iv infusion with loading dose">{{cite web |url=http://www.chm.davidson.edu/erstevens/iv%20load%20Cp%20v%20t/iv%20load%20Cp%20v%20t.html |title=Cp vs time - iv infusion with loading dose |work= |accessdate=}}</ref>
 
A loading dose is most useful for drugs that are [[Clearance (medicine)|eliminated from the body]] relatively slowly. Such drugs need only a low maintenance dose in order to keep the amount of the drug in the body at the appropriate level, but this also means that, without an initial higher dose, it would take a long time for the amount of the drug in the body to reach that level.
 
== Calculating the maintenance dose ==
 
The required maintenance dose may be calculated as:
 
:<math>\mbox{MD} = \frac{C_p CL}{F }</math>
 
Where:
:{|
| ''MD'' || is the maintenance dose rate [mg/h]
|-
| ''C<sub>p</sub>'' || = desired peak [[concentration]] of drug [mg/L]
|-
| ''CL'' || = [[Clearance (medicine)|clearance]] of drug in body [L/h]
|-
| ''F'' || = [[bioavailability]]
|}
 
For an intravenously administered drug, the bioavailability ''F'' will equal 1, since the drug is directly introduced to the bloodstream. If the patient requires an oral dose, bioavailability will be less than 1 (depending upon absorption, first pass metabolism etc.), requiring a larger loading dose.
 
== See also ==
* [[Therapeutic index]]
 
==References==
{{reflist}}
 
{{Pharmacology}}
 
[[Category:Pharmacology]]
 
 
{{pharma-stub}}

Latest revision as of 05:26, 13 July 2014

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