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{{enzyme
| Name = imidazoleacetate 4-monooxygenase
| EC_number = 1.14.13.5
| CAS_number = 9029-65-6
| IUBMB_EC_number = 1/14/13/5
| GO_code = 0047717
| image = 
| width = 
| caption = 
}}
In [[enzymology]], an '''imidazoleacetate 4-monooxygenase''' ({{EC number|1.14.13.5}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:4-imidazoleacetate + NADH + H<sup>+</sup> + O<sub>2</sub> <math>\rightleftharpoons</math> 5-hydroxy-4-imidazoleacetate + NAD<sup>+</sup> + H<sub>2</sub>O

The 4 [[substrate (biochemistry)|substrates]] of this enzyme are [[4-imidazoleacetate]], [[nicotinamide adenine dinucleotide|NADH]], [[hydrogen ion|H<sup>+</sup>]], and [[oxygen|O<sub>2</sub>]], whereas its 3 [[product (chemistry)|products]] are [[5-hydroxy-4-imidazoleacetate]], [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], and [[water|H<sub>2</sub>O]].

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor.  The systematic name of this enzyme class is '''4-imidazoleacetate,NADH:oxygen oxidoreductase (5-hydroxylating)'''. Other names in common use include '''imidazoleacetic hydroxylase''', '''imidazoleacetate hydroxylase''', and '''imidazoleacetic monooxygenase'''.  This enzyme participates in [[histidine metabolism]].  It employs one [[cofactor (biochemistry)|cofactor]], [[FAD]].  

==References==
{{reflist|1}}
* {{cite journal | author = Maki Y, Yamamoto S, Nozaki M, Hayaishi O | date = 1969 | title = Studies on monooxygenases. II. Crystallization and some properties of imidazole acetate monooxygenase | journal = J. Biol. Chem.  | volume = 244 | pages = 2942&ndash;50  | pmid = 5772468 | issue = 11 }}

{{1.14.13-enzyme-stub}}

[[Category:EC 1.14.13]]
[[Category:NADPH-dependent enzymes]]
[[Category:NADH-dependent enzymes]]
[[Category:Flavin enzymes]]
[[Category:Enzymes of unknown structure]]