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{{enzyme
| Name = alanine-tRNA ligase
| EC_number = 6.1.1.7
| CAS_number = 9031-71-4
| IUBMB_EC_number = 6/1/1/7
| GO_code = 0004813
| image = 
| width = 
| caption = 
}}
In [[enzymology]], an '''alanine-tRNA ligase''' ({{EC number|6.1.1.7}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:ATP + L-alanine + tRNAAla <math>\rightleftharpoons</math> AMP + diphosphate + L-alanyl-tRNAAla

The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine triphosphate|ATP]], [[L-alanine]], and [[tRNA(Ala)]], whereas its 3 [[product (chemistry)|products]] are [[adenosine monophosphate|AMP]], [[diphosphate]], and [[L-alanyl-tRNA(Ala)]].

This enzyme belongs to the family of [[ligase]]s, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds.  The systematic name of this enzyme class is '''L-alanine:tRNAAla ligase (AMP-forming)'''. Other names in common use include '''alanyl-tRNA synthetase''', '''alanyl-transfer ribonucleate synthetase''', '''alanyl-transfer RNA synthetase''', '''alanyl-transfer ribonucleic acid synthetase''', '''alanine-transfer RNA ligase''', '''alanine transfer RNA synthetase''', '''alanine tRNA synthetase''', '''alanine translase''', '''alanyl-transfer ribonucleate synthase''', '''AlaRS''', and '''Ala-tRNA synthetase'''.  This enzyme participates in [[alanine and aspartate metabolism]] and [[aminoacyl-trna biosynthesis]].

==See also==
*[[Sticky mouse]] - mutation in the gene

==Structural studies==

As of late 2007, 7 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1RIQ}}, {{PDB link|1V4P}}, {{PDB link|1YFR}}, {{PDB link|1YFS}}, {{PDB link|1YFT}}, {{PDB link|1YGB}}, and {{PDB link|2E1B}}.

==References==
{{reflist|1}}
* {{cite journal | author = HOLLEY RW, GOLDSTEIN J | year = 1959 | title = An alanine-dependent, ribonuclease-inhibited conversion of adenosine 5'-phosphate to adenosine triphosphate. II. Reconstruction of the system from purified components | journal = J. Biol. Chem.  | volume = 234 | pages = 1765&ndash;8  | pmid = 13672960 | issue = 7 }}
* {{cite journal | author = Webster GC | year = 1961 | title = Isolation of an alanine-activating enzyme from pig liver | journal = Biochim. Biophys. Acta  | volume = 49 | pages = 141&ndash;152 | doi = 10.1016/0006-3002(61)90877-0 | pmid = 13783653 }}

{{Ligases}}

{{DEFAULTSORT:Alanine-tRNA ligase}}
[[Category:EC 6.1.1]]
[[Category:Enzymes of known structure]]


{{ligase-stub}}