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{{enzyme
| Name = 3',5'-cyclic-GMP phosphodiesterase
| EC_number = 3.1.4.35
| CAS_number = 9068-52-4
| IUBMB_EC_number = 3/1/4/35
| GO_code = 0047555
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''3',5'-cyclic-GMP phosphodiesterase''' ({{EC number|3.1.4.35}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:guanosine 3',5'-cyclic phosphate + H<sub>2</sub>O <math>\rightleftharpoons</math> guanosine 5'-phosphate

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[guanosine 3',5'-cyclic phosphate]] and [[water|H<sub>2</sub>O]], whereas its [[product (chemistry)|product]] is [[guanosine 5'-phosphate]].

This enzyme belongs to the family of [[hydrolase]]s, specifically those acting on phosphoric [[ester|diester]] bonds.  The systematic name of this enzyme class is '''3',5'-cyclic-GMP 5'-nucleotidohydrolase'''. Other names in common use include '''guanosine cyclic 3',5'-phosphate phosphodiesterase''', '''cyclic GMP phosphodiesterase''', '''cyclic 3',5'-GMP phosphodiesterase''', '''cyclic guanosine 3',5'-monophosphate phosphodiesterase''', '''cyclic guanosine 3',5'-phosphate phosphodiesterase''', '''cGMP phosphodiesterase''', '''cGMP-PDE''', and '''cyclic guanosine 3',5'-phosphate phosphodiesterase'''.

==Structural studies==

As of late 2007, 5 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1MC0}}, {{PDB link|2CHM}}, {{PDB link|2H40}}, {{PDB link|2H42}}, and {{PDB link|2H44}}.

==References==
{{reflist|1}}
* {{cite journal | author = Marks F and Raab I | year = 1974 | title = The second messenger system of mouse epidermis. IV. Cyclic AMP and cyclic GMP phosphodiesterase | journal = Biochim. Biophys. Acta  | volume = 334 | pages = 368&ndash;377 }}

{{Esterases}}

[[Category:EC 3.1.4]]
[[Category:Enzymes of known structure]]


{{hydrolase-stub}}