View source for (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase

{{Infobox enzyme
| Name = D-alanine—D-serine ligase
| EC_number = 6.3.2.35
| CAS_number = 
| IUBMB_EC_number = 6/3/2/35
| GO_code = 
| image = 
| width = 
| caption =
}}
'''D-alanine—D-serine ligase''' ({{EC number|6.3.2.35}}, ''VanC'', ''VanE'', ''VanG'') is an [[enzyme]] with system name ''D-alanine:D-serine ligase (ADP-forming)''.<ref>{{cite journal | title = Sequence of the ''vanC'' gene of ''Enterococcus gallinarum'' BM4174 encoding a D-alanine:D-alanine ligase-related protein necessary for vancomycin  resistance |author = Dutka-Malen, S., Molinas, C., Arthur, M. and Courvalin, P. |journal = Gene |year = 1992 |volume = 112 |pages = 53–58 |pmid = 1551598}}</ref><ref>{{cite journal | title = Bacterial resistance to vancomycin: overproduction, purification, and characterization of VanC2 from ''Enterococcus casseliflavus'' as a D-Ala-D-Ser ligase |author = Park, I.S., Lin, C.H. and Walsh, C.T. |journal = Proc. Natl. Acad. Sci. USA |year = 1997 |volume = 94 |pages = 10040–10044 |pmid = 9294159}}</ref><ref>{{cite journal | title = VanE, a new type of acquired glycopeptide resistance in ''Enterococcus faecalis'' BM4405 |author = Fines, M., Perichon, B., Reynolds, P., Sahm, D.F. and Courvalin, P. |journal = Antimicrob. Agents Chemother. |year = 1999 |volume = 43 |pages = 2161–2164 |pmid = 10471558}}</ref><ref>{{cite journal | title = The ''vanG'' glycopeptide resistance operon from ''Enterococcus faecalis'' revisited |author = Depardieu, F., Bonora, M.G., Reynolds, P.E. and Courvalin, P. |journal = Mol. Microbiol. |year = 2003 |volume = 50 |pages = 931–948 |pmid = 14617152}}</ref><ref>{{cite journal | title = Genetic diversity of the low-level vancomycin resistance gene ''vanC''-2/''vanC''-3 and identification of a novel ''vanC'' subtype (''vanC''-4) in ''Enterococcus casseliflavus'' |author = Watanabe, S., Kobayashi, N., Quinones, D., Hayakawa, S., Nagashima, S., Uehara, N. and Watanabe, N. |journal = Microb. Drug Resist. |year = 2009 |volume = 15 |pages = 1–9 |pmid = 19216682}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: D-[[alanine]] + D-[[serine]] + ATP <math>\rightleftharpoons</math> D-alanyl-D-serine + ADP + [[phosphate]]

The product of this enzyme, D-alanyl-D-serine, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide.

== References ==
{{reflist}}

== External links ==
* {{MeshName|D-alanine—D-serine+ligase}}

{{DEFAULTSORT:D-alanine-D-serine ligase}}
[[Category:EC 6.3.2]]