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{{Infobox enzyme
| Name = L-lysine cyclodeaminase
| EC_number = 4.3.1.28
| CAS_number = 
| IUBMB_EC_number = 4/3/1/28
| GO_code = 
| image = 
| width = 
| caption =
}}
'''L-lysine cyclodeaminase''' ({{EC number|4.3.1.28}}, ''rapL (gene)'', ''fkbL (gene)'', ''tubZ (gene)'', ''visC (gene)'') is an [[enzyme]] with system name ''L-lysine ammonia-lyase (cyclizing; ammonia-forming)''.<ref>{{cite journal | title = Mutational biosynthesis of novel rapamycins by a strain of <em>Streptomyces hygroscopicus</em> NRRL 5491 disrupted in <em>rapL</em>, encoding a putative lysine cyclodeaminase |author = Khaw, L.E., Bohm, G.A., Metcalfe, S., Staunton, J. and Leadlay, P.F. |journal = J. Bacteriol. |year = 1998 |volume = 180 |pages = 809–814 |pmid = 9473033 |issue=4}}</ref><ref>{{cite journal | title = Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster |author = Gatto, G.J., Jr., Boyne, M.T., 2nd, Kelleher, N.L. and Walsh, C.T. |journal = J. Am. Chem. Soc. |year = 2006 |volume = 128 |pages = 3838–3847 |pmid = 16536560 |doi=10.1021/ja0587603}}</ref><ref>{{cite journal | title = Biochemical characterisation of recombinant <em>Streptomyces</em> pristinaespiralis <small>L</small>-lysine cyclodeaminase |author = Tsotsou, G.E. and Barbirato, F. |journal = Biochimie |year = 2007 |volume = 89 |pages = 591–604 |pmid = 17291665 |doi=10.1016/j.biochi.2006.12.008 |issue=5}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: L-[[lysine]] <math>\rightleftharpoons</math> L-[[pipecolate]] + NH<sub>3</sub>

This enzyme requires bound NAD<sup>+</sup>. 

== References ==
{{reflist}}

== External links ==
* {{MeshName|L-lysine+cyclodeaminase}}

[[Category:EC 4.3.1]]