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{{Infobox enzyme
| Name = Cyclohexanone monooxygenase
| EC_number = 1.14.13.22
| CAS_number = 52037-90-8
| IUBMB_EC_number = 1/14/13/22
| GO_code =
| image =
| width =
| caption =
}}
'''Cyclohexanone monooxygenase''' ({{EC number|1.14.13.22}}, ''cyclohexanone 1,2-monooxygenase'', ''cyclohexanone oxygenase'', ''cyclohexanone:NADPH:oxygen oxidoreductase (6-hydroxylating, 1,2-lactonizing)'') is an [[enzyme]] with system name ''cyclohexanone,NADPH:oxygen oxidoreductase (lactone-forming)''.<ref>{{cite journal | title = The purification and properties of cyclohexanone oxygenase from <em>Nocardia globerula</em> CL1 and <em>Acinetobacter</em> NCIB 9871 |author = Donoghue, N.A., Morris, D.B. and Trudgill, P.W. |journal = Eur. J. Biochem. |year = 1976 |volume = 63 |pages = 175–192 |pmid = 1261545}}</ref><ref>{{cite journal | title = Mechanistic studies of cyclohexanone monooxygenase: chemical properties of intermediates involved in catalysis |author = Sheng, D., Ballou, D.P. and Massey, V. |journal = Biochemistry |year = 2001 |volume = 40 |pages = 11156–11167 |pmid = 11551214}}</ref><ref>{{cite journal | title = Cyclohexanone monooxygenase: a useful reagent for asymmetric Baeyer-Villiger reactions |author = Stewart, J.D. |journal = Curr. Org. Chem. |year = 1998 |volume = 2 |pages = 195–216 |pmid = }}</ref><ref>{{cite journal | title = Asymmetric oxidations at sulfur catalyzed by engineered strains that overexpress cyclohexanone monooxygenase |author = Chen, G., Kayser, M.M., Milhovilovic, M.D., Mrstik, M.E., Martinez, C.A. and Stewart, J.D. |journal = New J. Chem. |year = 1999 |volume = 23 |pages = 827–832 |pmid = }}</ref><ref>{{cite journal | title = First asymmetric oxidation of tertiary amines by cyclohexanone monooxygenase |author = Ottolina, G., Bianchi, S., Belloni, B., Carrea, G. and Danieli, B. |journal = Tetrahedron Lett. |year = 1999 |volume = 40 |pages = 8483–8486 |pmid = }}</ref><ref>{{cite journal | title = First asymmetric epoxidation catalysed by cyclohexanone monooxygenase |author = Colonna, S., Gaggero, N., Carrea, G., Ottolina, G., Pasta, P. and Zambianchi, F. |journal = Tetrahedron Lett. |year = 2002 |volume = 43 |pages = 1797–1799 |pmid = }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[cyclohexanone]] + NADPH + H<sup>+</sup> + O<sub>2</sub> <math>\rightleftharpoons</math> [[hexano-6-lactone]] + NADP<sup>+</sup> + H<sub>2</sub>O

Cyclohexanone monooxygenase is a flavoprotein (FAD). 

== References ==
{{reflist}}

== External links ==
* {{MeshName|Cyclohexanone+monooxygenase}}

[[Category:EC 1.14.13]]