View source for (Methionine synthase) reductase

{{enzyme
| Name = 1-hydroxy-2-naphthoate 1,2-dioxygenase
| EC_number = 1.13.11.38
| CAS_number = 85941-64-6
| IUBMB_EC_number = 1/13/11/38
| GO_code = 0018582
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''1-hydroxy-2-naphthoate 1,2-dioxygenase''' ({{EC number|1.13.11.38}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:1-hydroxy-2-naphthoate + O<sub>2</sub> <math>\rightleftharpoons</math> (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[1-hydroxy-2-naphthoate]] and [[oxygen|O<sub>2</sub>]], whereas its [[product (chemistry)|product]] is [[(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate]].

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on single donors with O<sub>2</sub> as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O<sub>2</sub>.  The systematic name of this enzyme class is '''1-hydroxy-2-naphthoate:oxygen 1,2-oxidoreductase (decyclizing)'''. Other names in common use include '''1-hydroxy-2-naphthoate dioxygenase''', '''1-hydroxy-2-naphthoate-degrading enzyme''', and '''1-hydroxy-2-naphthoic acid dioxygenase'''.  This enzyme participates in [[naphthalene and anthracene degradation]].  It employs one [[cofactor (biochemistry)|cofactor]], [[iron]].  

==References==
{{reflist|1}}
* {{cite journal | author = Barnsley EA | date = 1983 | title = Phthalate pathway of phenanthrene metabolism: formation of 2'-carboxybenzalpyruvate | journal = J. Bacteriol.  | volume = 154 | pages = 113&ndash;7  | pmid = 6833175 | issue = 1 | pmc = 217437 }}

[[Category:EC 1.13.11]]
[[Category:Iron enzymes]]
[[Category:Enzymes of unknown structure]]