View source for (Phosphatase 2A protein)-leucine-carboxy methyltransferase

{{Infobox enzyme
| Name = Protein N-terminal methyltransferase
| EC_number = 2.1.1.244
| CAS_number = 
| IUBMB_EC_number = 2/1/1/244
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Protein N-terminal methyltransferase''' ({{EC number|2.1.1.244}}, ''NMT1 (gene)'', ''METTL11A (gene)'') is an [[enzyme]] with system name ''S-adenosyl-L-methionine:N-terminal-(A,P,S)PK-(protein) methyltransferase''.<ref>{{cite journal | title = Identification of protein N-terminal methyltransferases in yeast and humans |author = Webb, K.J., Lipson, R.S., Al-Hadid, Q., Whitelegge, J.P. and Clarke, S.G. |journal = Biochemistry |date = 2010 |volume = 49 |pages = 5225-5235 |pmid = 20481588 |doi=10.1021/bi100428x}}</ref><ref>{{cite journal | title = NRMT is an &alpha;-<em>N</em>-methyltransferase that methylates RCC1 and retinoblastoma protein |author = Tooley, C.E., Petkowski, J.J., Muratore-Schroeder, T.L., Balsbaugh, J.L., Shabanowitz, J., Sabat, M., Minor, W., Hunt, D.F. and Macara, I.G. |journal = Nature |date = 2010 |volume = 466 |pages = 1125-1128 |pmid = 20668449 |doi=10.1038/nature09343}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

:(1) 3 [[S-adenosyl-L-methionine]] + N-terminal-(A,S)PK-[protein] <math>\rightleftharpoons</math> 3 [[S-adenosyl-L-homocysteine]] + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein] (overall reaction)
:(1a) S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] <math>\rightleftharpoons</math> S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-(A,S)PK-[protein]
:(1b) S-adenosyl-L-methionine + N-terminal-N-methyl-N-(A,S)PK-[protein] <math>\rightleftharpoons</math> S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-(A,S)PK-[protein]
:(1c) S-adenosyl-L-methionine + N-terminal-N,N-dimethyl-N-(A,S)PK-serine-[protein] <math>\rightleftharpoons</math> S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein]
:(2) 2 S-adenosyl-L-methionine + N-terminal-PPK-[protein] <math>\rightleftharpoons</math> 2 S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein] (overall reaction)
:(2a) S-adenosyl-L-methionine + N-terminal-PPK-[protein] <math>\rightleftharpoons</math> S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-PPK-[protein]
:(2b) S-adenosyl-L-methionine + N-terminal-N-methyl-N-PPK-[protein] <math>\rightleftharpoons</math> S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein]

This enzyme methylates the [[N-terminus]] of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys.
 
== References ==
{{reflist}}

== External links ==
* {{MeshName|Protein+N-terminal+methyltransferase}}

[[Category:EC 2.1.1]]