View source for 1,8-Cineole 2-endo-monooxygenase

{{Infobox enzyme
| Name = Sphinganine C4-monooxygenase
| EC_number = 1.14.13.169
| CAS_number = 
| IUBMB_EC_number = 1/14/13/169
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Sphinganine C4-monooxygenase''' ({{EC number|1.14.13.169}}, ''sphingolipid C4-hydroxylase'', ''SUR2 (gene)'', ''SBH1 (gene)'', ''SBH2 (gene)'') is an [[enzyme]] with system name ''sphinganine,NADPH:oxygen oxidoreductase (C4-hydroxylating)''.<ref>{{cite journal | title = Hydroxylation of <em>Saccharomyces cerevisiae</em> ceramides requires Sur2p and Scs7p |author = Haak, D., Gable, K., Beeler, T. and Dunn, T. |journal = J. Biol. Chem. |year = 1997 |volume = 272 |pages = 29704–29710 |pmid = 9368039}}</ref><ref>{{cite journal | title = Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in <em>Saccharomyces cerevisiae</em> |author = Grilley, M.M., Stock, S.D., Dickson, R.C., Lester, R.L. and Takemoto, J.Y. |journal = J. Biol. Chem. |year = 1998 |volume = 273 |pages = 11062–11068 |pmid = 9556590}}</ref><ref>{{cite journal | title = Functional characterization of sphingolipid C4-hydroxylase genes from <em>Arabidopsis thaliana</em> |author = Sperling, P., Ternes, P., Moll, H., Franke, S., Zahringer, U. and Heinz, E. |journal = FEBS Lett |year = 2001 |volume = 494 |pages = 90–94 |pmid = 11297741}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[sphinganine]] + NADPH + H<sup>+</sup> + O<sub>2</sub> <math>\rightleftharpoons</math> [[phytosphingosine]] + NADP<sup>+</sup> + H<sub>2</sub>O

Sphinganine C4-monooxygenase is involved in the biosynthesis of [[sphingolipids]] in [[yeast]] and [[plant]]s.

== References ==
{{reflist}}

== External links ==
* {{MeshName|Sphinganine+C4-monooxygenase}}

[[Category:EC 1.14.13]]