View source for 1-pyrroline-4-hydroxy-2-carboxylate deaminase

{{enzyme
| Name = 5-oxoprolinase (ATP-hydrolyzing)
| EC_number = 3.5.2.9
| CAS_number = 9075-46-1
| IUBMB_EC_number = 3/5/2/9
| GO_code = 0017168
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''5-oxoprolinase (ATP-hydrolysing)''' ({{EC number|3.5.2.9}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:ATP + 5-oxo-L-proline + 2 H<sub>2</sub>O <math>\rightleftharpoons</math> ADP + phosphate + L-glutamate

The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine triphosphate|ATP]], [[5-oxo-L-proline]], and [[water|H<sub>2</sub>O]], whereas its 3 [[product (chemistry)|products]] are [[adenosine diphosphate|ADP]], [[phosphate]], and [[L-glutamate]].

This enzyme belongs to the family of [[hydrolase]]s, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides.  The systematic name of this enzyme class is '''5-oxo-L-proline amidohydrolase (ATP-hydrolysing)'''. Other names in common use include '''pyroglutamase (ATP-hydrolysing)''', '''oxoprolinase''', '''pyroglutamase''', '''5-oxoprolinase''', '''pyroglutamate hydrolase''', '''pyroglutamic hydrolase''', '''L-pyroglutamate hydrolase''', '''5-oxo-L-prolinase''', and '''pyroglutamase'''.  This enzyme participates in [[glutathione metabolism]].  

==References==
{{reflist|1}}
* {{cite journal | author = Van der Werf P, Orlowski M, Meister A | date = 1971 | title = Enzymatic conversion of 5-oxo-L-proline (L-pyrrolidone carboxylate) to L-glutamate coupled with cleavage of adenosine triphosphate to adenosine diphosphate, a reaction in the  -glutamyl cycle | journal = Proc. Natl. Acad. Sci. U.S.A.  | volume = 68 | pages = 2982&ndash;5  | pmid = 5289242 | doi = 10.1073/pnas.68.12.2982 | issue = 12 | pmc = 389574 }}

[[Category:EC 3.5.2]]
[[Category:Enzymes of unknown structure]]


{{hydrolase-stub}}