View source for 16S rRNA (adenine1408-N1)-methyltransferase

{{Infobox enzyme
| Name = 23S rRNA (adenine<sup>2503</sup>-C<sup>2</sup>)-methyltransferase
| EC_number = 2.1.1.192
| CAS_number = 
| IUBMB_EC_number = 2/1/1/192
| GO_code = 
| image = 
| width = 
| caption =
}}
'''23S rRNA (adenine<sup>2503</sup>-C<sup>2</sup>)-methyltransferase''' ({{EC number|2.1.1.192}}, ''RlmN'', ''YfgB'', ''Cfr'') is an [[enzyme]] with system name ''S-adenosyl-L-methionine:23S rRNA (adenine<sup>2503</sup>-C<sup>2</sup>)-methyltransferase''.<ref>{{cite journal | title = The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA |author = Toh, S.M., Xiong, L., Bae, T. and Mankin, A.S. |journal = RNA |year = 2008 |volume = 14 |pages = 98–106 |pmid = 18025251 | doi = 10.1261/rna.814408 | issue = 1 | pmc = 2151032}}</ref><ref>{{cite journal | title = RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA |author = Yan, F., LaMarre, J.M., RÃ¶hrich, R., Wiesner, J., Jomaa, H., Mankin, A.S., Fujimori, D.G. |journal = J. Am. Chem. Soc. |year = 2010 |volume = 132 |pages = 3953–3964 |pmid = 20184321 | doi = 10.1021/ja910850y | issue = 11 | pmc = 2859901}}</ref><ref>{{cite journal | title = RNA methylation by Radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift |author = Yan, F. and Fujimori, D.G. |journal = Proc. Natl. Acad. Sci. USA |year = 2011 |volume = 108 |pages = 3930–3934 |pmid = 21368151 | doi = 10.1073/pnas.1017781108 | issue = 10 | pmc = 3054002}}</ref><ref>{{cite journal | title = A radically different mechanism for ''S''-adenosylmethionine-dependent methyltransferases |author = Grove, T.L., Benner, J.S., Radle, M.I., Ahlum, J.H., Landgraf, B.J., Krebs, C. and Booker, S.J. |journal = Science |year = 2011 |volume = 332 |pages = 604–607 |pmid = 21415317 | doi = 10.1126/science.1200877 | issue = 6029}}</ref><ref>{{cite journal | title = Structural basis for methyl transfer by a radical SAM enzyme |author = Boal, A.K., Grove, T.L., McLaughlin, M.I., Yennawar, N.H., Booker, S.J. and Rosenzweig, A.C. |journal = Science |year = 2011 |volume = 332 |pages = 544–545 |pmid = 21527678 | doi = 10.1126/science.1205358 | issue = 6033}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: 2 [[S-adenosyl-L-methionine]] + [[adenine]]<sup>2503</sup> in [[Ribosomal RNA|23S rRNA]] <math>\rightleftharpoons</math> <sup>S-adenosyl-L-homocysteine</sup> + L-[[methionine]] + [[5'-deoxyadenosine]] + [[2-methyladenine]]<sup>2503</sup> in 23S rRNA

23S rRNA (adenine<sup>2503</sup>-C<sup>2</sup>)-methyltransferase contains an [4Fe-4S] cluster.

== References ==
{{reflist}}

== External links ==
*{{MeshName|23S+rRNA+(adenine2503-C2)-methyltransferase}}

[[Category:EC 2.1.1]]