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{{enzyme
| Name = 2-methylcitrate synthase
| EC_number = 2.3.3.5
| CAS_number = 57827-78-8
| IUBMB_EC_number = 2/3/3/5
| GO_code = 0050440
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''2-methylcitrate synthase''' ({{EC number|2.3.3.5}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:propanoyl-CoA + H<sub>2</sub>O + oxaloacetate <math>\rightleftharpoons</math> (2R,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA

The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[propanoyl-CoA]], [[water|H<sub>2</sub>O]], and [[oxaloacetate]], whereas its two [[product (chemistry)|products]] are [[(2R,3S)-2-hydroxybutane-1,2,3-tricarboxylate]] and [[coenzyme A|CoA]].

This enzyme belongs to the family of [[transferase]]s, specifically those [[acyltransferases]] that convert acyl groups into alkyl groups on transfer.  The systematic name of this enzyme class is '''propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming)'''. Other names in common use include '''2-methylcitrate oxaloacetate-lyase''', '''MCS''', '''methylcitrate synthase''', and '''methylcitrate synthetase'''.  This enzyme participates in [[propanoate metabolism]].  

==References==
{{reflist|1}}
* {{cite journal | author = Uchiyama H and Tabuchi T | date = 1976 | title = Properties of methylcitrate synthase from Candida lipolytica | journal = Agric. Biol. Chem.  | volume = 40 | pages = 1411&ndash;1418 }}
* {{cite journal | author = Buckel W | date = 1997 | title = Propionate oxidation in Escherichia coli: evidence for operation of a methylcitrate cycle in bacteria | journal = Arch. Microbiol.  | volume = 168 | pages = 428&ndash;36  | pmid = 9325432 | doi = 10.1007/s002030050518 | last2 = Wendisch | first2 = VF | last3 = De Graaf | first3 = AA | last4 = Müller | first4 = U | last5 = Linder | first5 = MI | last6 = Linder | first6 = D | last7 = Buckel | first7 = W | issue = 5 }}
* {{cite journal | author = Horswill AR, Escalante-Semerena JC | date = 1999 | title = Salmonella typhimurium LT2 catabolizes propionate via the 2-methylcitric acid cycle | journal = J. Bacteriol.  | volume = 181 | pages = 5615&ndash;23  | pmid = 10482501 | issue = 18 | pmc = 94080 }}
* {{cite journal | author = Wadman SK | date = 1994 | title = Identification of the stereoisomeric configurations of methylcitric acid produced by si-citrate synthase and methylcitrate synthase using capillary gas chromatography-mass spectrometry | journal = J. Inherit. Metab. Dis.  | volume = 17 | pages = 738&ndash;47  | pmid = 7707698 | doi = 10.1007/BF00712017 | last2 = Mienie | first2 = LJ | last3 = Erasmus | first3 = E | last4 = De Wet | first4 = WJ | last5 = Ketting | first5 = D | last6 = Duran | first6 = M | last7 = Wadman | first7 = SK | issue = 6 }}

{{transferase-stub}}

[[Category:EC 2.3.3]]
[[Category:Enzymes of unknown structure]]