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{{Infobox enzyme
| Name = 2-haloacid dehalogenase (configuration-inverting)
| EC_number = 3.8.1.10
| CAS_number = 
| IUBMB_EC_number = 3/8/1/10
| GO_code = 
| image = 
| width = 
| caption =
}}
'''2-haloacid dehalogenase (configuration-inverting)''' ({{EC number|3.8.1.10}}, ''2-haloalkanoic acid dehalogenase'', ''2-haloalkanoid acid halidohydrolase'', ''DL-2-haloacid dehalogenase'', ''DL-2-haloacid dehalogenase (inversion of configuration)'', ''DL-2-haloacid halidohydrolase (inversion of configuration)'', ''DL-DEXi'', ''(R,S)-2-haloacid dehalogenase (configuration-inverting)'') is an [[enzyme]] with system name ''(S)-2-haloacid dehalogenase (configuration-inverting)''.<ref>{{cite journal | title = Bacterial assimilation of <small>D</small>- and <small>L</small>-2-chloropropionates and occurrence of a new dehalogenase |author = Motosugi, K., Esahi, N. and Soda, K. |journal = Arch. Microbiol. |year = 1982 |volume = 131 |pages = 179–183 |pmid = 7103659 |doi=10.1007/BF00405875}}</ref><ref>{{cite journal | title = 2-haloacid dehalogenase, from <em>Pseudomonas</em> sp |author = Motosugi, K., Esahi, N. and Soda, K. Purification and properties of a new enzyme, DL- |journal = J. Bacteriol. |year = 1982 |volume = 150 |pages = 522–527 |pmid = 7068529 |issue=2}}</ref><ref>{{cite journal | title = Enzymatic preparation of <small>D</small>- and <small>L</small>-lactic acid from racemic 2-chloropropionic acid |author = Motosugi, K., Esahi, N. and Soda, K. |journal = Biotechnol. Bioeng. |year = 1984 |volume = 26 |pages = 805–806 |pmid = 18889931 |issue=2}}</ref><ref>{{cite journal | title = Bacterial 2-haloacid dehalogenases: structures and reaction mechanisms |author = Kurihara, T., Esaki, N. and Soda, K. |journal = J. Mol. Catal., B Enzym. |year = 2000 |volume = 10 |pages = 57–65 |pmid = |doi=10.1016/S1381-1177(00)00108-9}}</ref><ref>{{cite journal | title = Purification and characterization of thermostable and nonthermostable 2-haloacid dehalogenases with different stereospecificities from <em>Pseudomonas</em> sp. strain YL |author = Liu, J.-Q., Kurihara, T., Hasan, A.K.M.Q., Nardi-Dei, V., Koshikawa, H., Esaki, N. and Soda, K. |journal = Appl. Environ. Microbiol. |year = 1994 |volume = 60 |pages = 2389–2393 |pmid = 8074519 |issue=7}}</ref><ref>{{cite journal | title = Cloning, sequencing and expression in <em>Escherichia coli</em> of two Rhizobium sp. genes encoding haloalkanoate dehalogenases of opposite stereospecificity |author = Cairns, S.S., Cornish, A. and Cooper, R.A. |journal = Eur. J. Biochem. |year = 1996 |volume = 235 |pages = 744–749 |pmid = 8654424 |issue=3}}</ref><ref>{{cite journal | title = Partial purification, stereospecificity and stoichiometry of three dehalogenases from a Rhizobium species |author = Leigh, J.A., Skinner, A.J. and Cooper, R.A. |journal = FEMS Microbiol. Lett. |year = 1988 |volume = 49 |pages = 353–356 |pmid = |doi=10.1111/j.1574-6968.1988.tb02756.x}}</ref><ref>{{cite journal | title = Stereospecificity of 2-monochloropropionate dehalogenation by the two dehalogenases of <em>Pseudomonas</em> P3: evidence for two different dehalogenation mechanisms |author = Weightman, A.J., Weightman, A.L. and Slater, J.H. |journal = J. Gen. Microbiol. |year = 1982 |volume = 128 |pages = 1755–1762 |pmid = 7142958 |issue=8}}</ref><ref>{{cite journal | title = Bacterial 2-haloacid dehalogenases: Structures and catalytic properties |author = Soda, K., Kurihara, T., Liu, J.-Q., Nardi-Dei, V., Park, C., Miyagi, M., Tsunasawa, S. and Esaki, N. |journal = Pure Appl. Chem. |year = 1996 |volume = 68 |pages = 2097–2103 |pmid = |doi=10.1351/pac199668112097}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: (1) (S)-2-haloacid + H<sub>2</sub>O <math>\rightleftharpoons</math> (R)-2-hydroxyacid + [[halide]]
: (2) (R)-2-haloacid + H<sub>2</sub>O <math>\rightleftharpoons</math> (S)-2-hydroxyacid + halide

This enzyme dehalogenates both (S)- and (R)-2-haloalkanoic acids.

== References ==
{{reflist}}

== External links ==
* {{MeshName|2-haloacid+dehalogenase+(configuration-inverting)}}

[[Category:EC 3.8.1]]