View source for 23S rRNA (adenine2503-C2,C8)-dimethyltransferase

{{Infobox enzyme
| Name = TRNA (cytidine<sup>32</sup>/guanosine<sup>34</sup>-2'-O)-methyltransferase
| EC_number = 2.1.1.205
| CAS_number = 
| IUBMB_EC_number = 2/1/1/205
| GO_code = 
| image = 
| width = 
| caption =
}}
'''TRNA (cytidine<sup>32</sup>/guanosine<sup>34</sup>-2'-O)-methyltransferase''' ({{EC number|2.1.1.205}}, ''Trm7p'') is an [[enzyme]] with system name ''S-adenosyl-L-methionine:tRNA (cytidine32/guanosine34-2'-O)-methyltransferase''.<ref>{{cite journal | title = Trm7p catalyses the formation of two 2&prime;-<em>O</em>-methylriboses in yeast tRNA anticodon loop |author = Pintard, L., Lecointe, F., Bujnicki, J.M., Bonnerot, C., Grosjean, H. and Lapeyre, B. |journal = EMBO J. |date = 2002 |volume = 21 |pages = 1811-1820 |pmid = 11927565}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[S-adenosyl-L-methionine]] + [[cytidine]]<sup>32</sup>/[[guanosine]]<sup>34</sup> in [[Transfer RNA|tRNA]] <math>\rightleftharpoons</math> [[S-adenosyl-L-homocysteine]] + 2'-O-methylcytidine<sup>32</sup>/2'-O-methylguanosine<sup>34</sup> in tRNA

The enzyme from ''[[Saccharomyces cerevisiae]]'' catalyses the formation of 2'-O-methylnucleotides at positions 32 and 34 of the [[yeast]] tRNAPhe and tRNATrp.

== References ==
{{reflist}}

== External links ==
* {{MeshName|TRNA+(cytidine32/guanosine34-2'-O)-methyltransferase}}

[[Category:EC 2.1.1]]