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{{enzyme
| Name = 2-hydroxyquinoline 5,6-dioxygenase
| EC_number = 1.14.12.16
| CAS_number = 172399-50-7
| IUBMB_EC_number = 1/14/12/16
| GO_code = 0018629
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''2-hydroxyquinoline 5,6-dioxygenase''' ({{EC number|1.14.12.16}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:quinolin-2-ol + NADH + H<sup>+</sup> + O<sub>2</sub> <math>\rightleftharpoons</math> 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD<sup>+</sup>

The 4 [[substrate (biochemistry)|substrates]] of this enzyme are [[quinolin-2-ol]], [[nicotinamide adenine dinucleotide|NADH]], [[hydrogen ion|H<sup>+</sup>]], and [[oxygen|O<sub>2</sub>]], whereas its two [[product (chemistry)|products]] are [[2,5,6-trihydroxy-5,6-dihydroquinoline]] and [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]].

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of two atoms o oxygen into the other donor.  The systematic name of this enzyme class is '''quinolin-2-ol,NADH:oxygen oxidoreductase (5,6-hydroxylating)'''. Other names in common use include '''2-oxo-1,2-dihydroquinoline 5,6-dioxygenase''', '''quinolin-2-ol 5,6-dioxygenase''', and '''quinolin-2(1H)-one 5,6-dioxygenase'''.  

==References==
{{reflist|1}}
* {{cite journal | author = Schach S, Tshisuaka B, Fetzner S, Lingens F | date = 1995 | title = Quinoline 2-oxidoreductase and 2-oxo-1,2-dihydroquinoline 5,6-dioxygenase from Comamonas testosteroni 63. The first two enzymes in quinoline and 3-methylquinoline degradation | journal = Eur. J. Biochem.  | volume = 232 | pages = 536&ndash;44  | pmid = 7556204 | doi = 10.1111/j.1432-1033.1995.tb20841.x | issue = 2 }}

{{1.14-enzyme-stub}}

[[Category:EC 1.14.12]]
[[Category:NADPH-dependent enzymes]]
[[Category:NADH-dependent enzymes]]
[[Category:Enzymes of unknown structure]]