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{{Infobox enzyme
| Name = Tryptophan N-monooxygenase
| EC_number = 1.14.13.125
| CAS_number = 
| IUBMB_EC_number = 1/14/13/125
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Tryptophan N-monooxygenase''' ({{EC number|1.14.13.125}}, ''tryptophan N-hydroxylase'', ''CYP79B1'', ''CYP79B2'', ''CYP79B3'') is an [[enzyme]] with system name ''L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating)''.<ref>{{cite journal | title = Cytochrome ''P''<sub>450</sub> CYP79B2 from ''Arabidopsis'' catalyzes the conversion of tryptophan to indole-3-acetaldoxime, a precursor of indole glucosinolates and indole-3-acetic acid |author = Mikkelsen, M.D., Hansen, C.H., Wittstock, U. and Halkier, B.A. |journal = J. Biol. Chem. |year = 2000 |volume = 275 |pages = 33712–33717 |pmid = 10922360 |doi=10.1074/jbc.M001667200 |issue=43}}</ref><ref>{{cite journal | title = ''Arabidopsis'' cytochrome ''P''<sub>450</sub>s that catalyze the first step of tryptophan-dependent indole-3-acetic acid biosynthesis |author = Hull, A.K., Vij, R. and Celenza, J.L. |journal = Proc. Natl. Acad. Sci. USA |year = 2000 |volume = 97 |pages = 2379–2384 |pmid = 10681464 |doi=10.1073/pnas.040569997 |issue=5 |pmc=15809}}</ref><ref>{{cite journal | title = Trp-dependent auxin biosynthesis in ''Arabidopsis'': involvement of cytochrome ''P''<sub>450</sub>s CYP79B2 and CYP79B3 |author = Zhao, Y., Hull, A.K., Gupta, N.R., Goss, K.A., Alonso, J., Ecker, J.R., Normanly, J., Chory, J. and Celenza, J.L. |journal = Genes Dev. |year = 2002 |volume = 16 |pages = 3100–3112 |pmid = 12464638 |doi=10.1101/gad.1035402 |issue=23 |pmc=187496}}</ref><ref>{{cite journal | title = CYP79B1 from ''Sinapis alba'' converts tryptophan to indole-3-acetaldoxime |author = Naur, P., Hansen, C.H., Bak, S., Hansen, B.G., Jensen, N.B., Nielsen, H.L. and Halkier, B.A. |journal = Arch. Biochem. Biophys. |year = 2003 |volume = 409 |pages = 235–241 |pmid = 12464264 |issue=1}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: L-[[tryptophan]] + 2 O<sub>2</sub> + 2 NADPH + 2 H<sup>+</sup> <math>\rightleftharpoons</math> (E)-indol-3-ylacetaldoxime + 2 NADP<sup>+</sup> + CO<sub>2</sub> + 3 H<sub>2</sub>O (overall reaction)
:(1a) L-tryptophan + O<sub>2</sub> + NADPH + H<sup>+</sup> <math>\rightleftharpoons</math> N-hydroxy-L-tryptophan + NADP<sup>+</sup> + H<sub>2</sub>O
:(1b) N-hydroxy-L-tryptophan + O<sub>2</sub> + NADPH + H<sup>+</sup> <math>\rightleftharpoons</math> N,N-dihydroxy-L-tryptophan + NADP<sup>+</sup> + H<sub>2</sub>O
:(1c) N,N-dihydroxy-L-tryptophan <math>\rightleftharpoons</math> (E)-indol-3-ylacetaldoxime + CO<sub>2</sub> + H<sub>2</sub>O

Tryptophan N-monooxygenase is a [[heme]]-[[thiol]]ate protein (P-450).

== References ==
{{reflist}}

== External links ==
* {{MeshName|Tryptophan+N-monooxygenase}}

[[Category:EC 1.14.13]]