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{{Infobox enzyme
| Name = Biflaviolin synthase
| EC_number = 1.14.21.7
| CAS_number = 
| IUBMB_EC_number = 1/14/21/7
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Biflaviolin synthase''' ({{EC number|1.14.21.7}}, ''CYP158A2'', ''CYP 158A2'', ''cytochrome P450 158A2'') is an [[enzyme]] with system name ''flaviolin,NADPH:oxygen oxidoreductase''.<ref>{{cite journal | title = Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of <em>Streptomyces coelicolor</em> A3(2) cytochrome P450 158A2 |author = Zhao, B., Guengerich, F.P., Bellamine, A., Lamb, D.C., Izumikawa, M., Lei, L., Podust, L.M., Sundaramoorthy, M., Kalaitzis, J.A., Reddy, L.M., Kelly, S.L., Moore, B.S., Stec, D., Voehler, M., Falck, J.R., Shimada, T. and Waterman, M.R. |journal = J. Biol. Chem. |year = 2005 |volume = 280 |pages = 11599–11607 |pmid = 15659395 |doi=10.1074/jbc.M410933200 |issue=12}}</ref><ref>{{cite journal | title = Role of active site water molecules and substrate hydroxyl groups in oxygen activation by cytochrome P450 158A2: a new mechanism of proton  transfer |author = Zhao, B., Guengerich, F.P., Voehler, M. and Waterman, M.R. |journal = J. Biol. Chem. |year = 2005 |volume = 280 |pages = 42188–42197 |pmid = 16239228 |doi=10.1074/jbc.M509220200 |issue=51}}</ref><ref>{{cite journal | title = Different binding modes of two flaviolin substrate molecules in cytochrome P450 158A1 (CYP158A1) compared to CYP158A2 |author = Zhao, B., Lamb, D.C., Lei, L., Kelly, S.L., Yuan, H., Hachey, D.L. and Waterman, M.R. |journal = Biochemistry |year = 2007 |volume = 46 |pages = 8725–8733 |pmid = 17614370 |doi=10.1021/bi7006959 |issue=30}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: (1) 2 [[flaviolin]] + NADPH + H<sup>+</sup> + O<sub>2</sub> <math>\rightleftharpoons</math> 3,3'-biflaviolin + NADP<sup>+</sup> + 2 H<sub>2</sub>O
: (2) 2 flaviolin + NADPH + H<sup>+</sup> + O<sub>2</sub> <math>\rightleftharpoons</math> 3,8'-biflaviolin + NADP<sup>+</sup> + 2 H<sub>2</sub>O

This [[cytochrome P450]] enzyme, from the soil-dwelling [[bacterium]] ''[[Streptomyces coelicolor]]'' A3(2), catalyses a [[phenol]] [[oxidation]] C-C coupling reaction.

== References ==
{{reflist}}

== External links ==
* {{MeshName|Biflaviolin+synthase}}

[[Category:EC 1.14.21]]