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{{Infobox enzyme
| Name = Tetrahydrocannabinolic acid synthase
| EC_number = 1.21.3.7
| CAS_number = 
| IUBMB_EC_number = 1/21/3/7
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Tetrahydrocannabinolic acid synthase''' ({{EC number|1.21.3.7}}, ''THCA synthase'', ''Delta1-tetrahydrocannabinolic acid synthase'') is an [[enzyme]] with system name ''cannabigerolate:oxygen oxidoreductase (cyclizing, Delta9-tetrahydrocannabinolate-forming)''.<ref>{{cite journal | title = First direct evidence for the mechanism of &Delta;<sup>1</sup>-tetrahydrocannabinolic acid biosynthesis |author = Taura, F., Morimoto, S. Shoyama, Y. and Mechoulam, R. |journal = J. Am. Chem. Soc. |year = 1995 |volume = 117 |pages = 9766–9767 |pmid = }}</ref><ref>{{cite journal | title = The gene controlling marijuana psychoactivity: molecular cloning and heterologous expression of &Delta;<sup>1</sup>-tetrahydrocannabinolic acid synthase from ''Cannabis sativa'' L |author = Sirikantaramas, S., Morimoto, S., Shoyama, Y., Ishikawa, Y., Wada, Y., Shoyama, Y. and Taura, F. |journal = J. Biol. Chem. |year = 2004 |volume = 279 |pages = 39767–39774 |pmid = 15190053 |doi=10.1074/jbc.M403693200 |issue=38}}</ref><ref>{{cite journal | title = Crystallization of &Delta;<sup>1</sup>-tetrahydrocannabinolic acid (THCA) synthase from ''Cannabis sativa'' |author = Shoyama, Y., Takeuchi, A., Taura, F., Tamada, T., Adachi, M., Kuroki, R., Shoyama, Y. and Morimoto, S. |journal = Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. |year = 2005 |volume = 61 |pages = 799–801 |pmid = 16511162 |doi=10.1107/S1744309105023365 |issue=Pt 8}}</ref><ref>{{cite journal | title = Structure and function of 1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of ''Cannabis sativa'' |author = Shoyama, Y., Tamada, T., Kurihara, K., Takeuchi, A., Taura, F., Arai, S., Blaber, M., Shoyama, Y., Morimoto, S. and Kuroki, R. |journal = J. Mol. Biol. |year = 2012 |volume =  423|pages = - |pmid = 22766313 |doi=10.1016/j.jmb.2012.06.030 |issue=1}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[cannabigerolate]] + O<sub>2</sub> <math>\rightleftharpoons</math> Delta9-tetrahydrocannabinolate + H<sub>2</sub>O<sub>2</sub>

Tetrahydrocannabinolic acid synthase is a [[flavoprotein]] (FAD).

== References ==
{{reflist}}

== External links ==
* {{MeshName|Tetrahydrocannabinolic+acid+synthase}}

[[Category:EC 1.21.3]]