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{{Infobox enzyme
| Name = Coenzyme F420-1:gamma-L-glutamate ligase
| EC_number = 6.3.2.34
| CAS_number = 
| IUBMB_EC_number = 6/3/2/34
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Coenzyme F420-1:gamma-L-glutamate ligase''' ({{EC number|6.3.2.34}}, ''F420:gamma-glutamyl ligase'', ''CofE-AF'', ''MJ0768'', ''CofE'') is an [[enzyme]] with system name ''L-glutamate:coenzyme F420-1 ligase (GDP-forming)''.<ref>{{cite journal | title = CofE catalyzes the addition of two glutamates to F<small><sub>420</sub></small>-0 in F<small><sub>420</sub></small> coenzyme biosynthesis in <em>Methanococcus jannaschii</em> |author = Li, H., Graupner, M., Xu, H. and White, R.H. |journal = Biochemistry |year = 2003 |volume = 42 |pages = 9771–9778 |pmid = 12911320}}</ref><ref>{{cite journal | title = Structure of an amide bond forming F<small><sub>420</sub></small>:&gamma;-glutamyl ligase from <em>Archaeoglobus fulgidus</em> &mdash; a member of a new family of non-ribosomal  peptide synthases |author = Nocek, B., Evdokimova, E., Proudfoot, M., Kudritska, M., Grochowski, L.L., White, R.H., Savchenko, A., Yakunin, A.F., Edwards, A. and Joachimiak, A. |journal = J. Mol. Biol. |year = 2007 |volume = 372 |pages = 456–469 |pmid = 17669425}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: GTP + coenzyme F420-1 + L-glutamate <math>\rightleftharpoons</math> GDP + phosphate + coenzyme gamma-F420-2

This protein catalyses the successive addition of two glutamate residues to cofactor F420 by two distinct and independent reactions. I

== References ==
{{reflist}}

== External links ==
* {{MeshName|Coenzyme+F420-1:gamma-L-glutamate+ligase}}

[[Category:EC 6.3.2]]