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{{enzyme
| Name = aldose 1-epimerase
| EC_number = 5.1.3.3
| CAS_number = 9031-76-9
| IUBMB_EC_number = 5/1/3/3
| GO_code = 0004034
| image = 
| width = 
| caption = 
}}
In [[enzymology]], an '''aldose 1-epimerase''' ({{EC number|5.1.3.3}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:alpha-D-glucose <math>\rightleftharpoons</math> beta-D-glucose

Hence, this enzyme has one [[substrate (biochemistry)|substrate]], [[alpha-D-glucose]], and one [[product (chemistry)|product]], [[beta-D-glucose]].

This enzyme belongs to the family of [[isomerase]]s, specifically those [[racemase]]s and [[epimerase]]s acting on [[carbohydrate]]s and derivatives.  The systematic name of this enzyme class is '''aldose 1-epimerase'''. Other names in common use include '''mutarotase''', and '''aldose mutarotase'''.  This enzyme participates in [[glycolysis]] and  [[gluconeogenesis]].  

==Structural studies==

As of late 2007, 23 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1L7J}}, {{PDB link|1L7K}}, {{PDB link|1LUR}}, {{PDB link|1MMU}}, {{PDB link|1MMX}}, {{PDB link|1MMY}}, {{PDB link|1MMZ}}, {{PDB link|1MN0}}, {{PDB link|1NS0}}, {{PDB link|1NS2}}, {{PDB link|1NS4}}, {{PDB link|1NS7}}, {{PDB link|1NS8}}, {{PDB link|1NSM}}, {{PDB link|1NSR}}, {{PDB link|1NSS}}, {{PDB link|1NSU}}, {{PDB link|1NSV}}, {{PDB link|1NSX}}, {{PDB link|1NSZ}}, {{PDB link|1SNZ}}, {{PDB link|1SO0}}, and {{PDB link|1YGA}}.

==References==
{{reflist|1}}
* {{cite journal | author = Bentley R and Bhate DS | date = 1960 | title = Mutarotase from Penicillium notatum. I. Purification, assay, and general properties of the enzyme | journal = J. Biol. Chem.  | volume = 235 | pages = 1219&ndash;1224 | pmid = 13799037 | url=http://www.jbc.org/content/235/5/1219.full.pdf | format=PDF | issue=5}}
* {{cite journal | author = Bentley R and Bhate DS | date = 1960 | title = Mutarotase from Penicillium notatum. II. The mechanism of the mutarotation reaction | journal = J. Biol. Chem.  | volume = 235 | pages = 1225&ndash;1233 | pmid = 13799038 | url=http://www.jbc.org/content/235/5/1225.full.pdf | format = PDF | issue=5}}
* {{cite journal | author = KEILIN D, HARTREE EF | date = 1952 | title = Biological catalysis of mutarotation of glucose | journal = Biochem. J.  | volume = 50 | pages = 341&ndash;8  | pmid = 14915955 | issue = 3 | pmc = 1197658 }}
* {{cite journal | author = LEVY GB, COOK ES | date = 1954 | title = A rotographic study of mutarotase | journal = Biochem. J.  | volume = 57 | pages = 50&ndash;5  | pmid = 13159947 | issue = 1 | pmc = 1269703 }}

{{isomerase-stub}}

[[Category:EC 5.1.3]]
[[Category:Enzymes of known structure]]