View source for 5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase

{{Infobox enzyme
| Name = TRNA (pseudouridine<sup>54</sup>-N<sup>1</sup>)-methyltransferase
| EC_number = 2.1.1.257
| CAS_number = 
| IUBMB_EC_number = 2/1/1/257
| GO_code = 
| image = 
| width = 
| caption =
}}
'''TRNA (pseudouridine<sup>54</sup>-N<sup>1</sup>)-methyltransferase''' ({{EC number|2.1.1.257}}, ''TrmY'', ''m1Psi methyltransferase'') is an [[enzyme]] with system name ''S-adenosyl-L-methionine:tRNA (pseudouridine54-N1)-methyltransferase''.<ref>{{cite journal | title = Crystal structure of Mj1640/DUF358 protein reveals a putative SPOUT-class RNA methyltransferase |author = Chen, H.Y. and Yuan, Y.A. |journal = J. Mol. Cell. Biol. |year = 2010 |volume = 2 |pages = 366–374 |pmid = 21098051}}</ref><ref>{{cite journal | title = Identification of the enzyme responsible for ''N''<sup>1</sup>-methylation of pseudouridine 54 in archaeal tRNAs |author = Wurm, J.P., Griese, M., Bahr, U., Held, M., Heckel, A., Karas, M., Soppa, J. and Wohnert, J. |journal = RNA |year = 2012 |volume = 18 |pages = 412–420 |pmid = 22274954}}</ref><ref>{{cite journal | title = The archaeal COG1901/DUF358 SPOUT-methyltransferase members, together with pseudouridine synthase Pus10, catalyze the formation of 1-methylpseudouridine at  position 54 of tRNA |author = Chatterjee, K., Blaby, I.K., Thiaville, P.C., Majumder, M., Grosjean, H., Yuan, Y.A., Gupta, R. and de Crecy-Lagard, V. |journal = RNA |year = 2012 |volume = 18 |pages = 421–433 |pmid = 22274953}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[S-adenosyl-L-methionine]] + [[pseudouridine]]<sup>54</sup> in tRNA <math>\rightleftharpoons</math> [[S-adenosyl-L-homocysteine]] + N<sup>1</sup>-[[methylpseudouridine]]<sup>54</sup> in tRNA

This [[archaea]]l enzyme is specific for the 54 position.

== References ==
{{reflist}}

== External links ==
* {{MeshName|TRNA+(pseudouridine54-N1)-methyltransferase}}

[[Category:EC 2.1.1]]