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{{Infobox enzyme
| Name = Dichloroarcyriaflavin A synthase
| EC_number = 1.13.12.17
| CAS_number = 
| IUBMB_EC_number = 1/13/12/17
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Dichloroarcyriaflavin A synthase''' ({{EC number|1.13.12.17}}) is an [[enzyme]] with system name ''dichlorochromopyrrolate,NADH:oxygen 2,5-oxidoreductase (dichloroarcyriaflavin A-forming)''.<ref>{{cite journal | title = Crystal structures and catalytic mechanism of cytochrome ''P''<sub>450</sub> StaP that produces the indolocarbazole skeleton |author = Makino, M., Sugimoto, H., Shiro, Y., Asamizu, S., Onaka, H. and Nagano, S. |journal = Proc. Natl. Acad. Sci. USA |year = 2007 |volume = 104 |pages = 11591–11596 |pmid = 17606921 |doi=10.1073/pnas.0702946104 |issue=28 |pmc=1913897}}</ref><ref>{{cite journal | title = Staurosporine and rebeccamycin aglycones are assembled by the oxidative action of StaP, StaC, and RebC on chromopyrrolic acid |author = Howard-Jones, A.R. and Walsh, C.T. |journal = J. Am. Chem. Soc. |year = 2006 |volume = 128 |pages = 12289–12298 |pmid = 16967980 |doi=10.1021/ja063898m |issue=37}}</ref><ref>{{cite journal | title = Combinatorial biosynthesis of antitumor indolocarbazole compounds |author = Sanchez, C., Zhu, L., Brana, A.F., Salas, A.P., Rohr, J., Mendez, C. and Salas, J.A. |journal = Proc. Natl. Acad. Sci. USA |year = 2005 |volume = 102 |pages = #461–466 |pmid = 15625109 |doi=10.1073/pnas.0407809102 |issue=2 |pmc=544307}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[dichlorochromopyrrolate]] + 4 O<sub>2</sub> + 4 NADH + 4 H<sup>+</sup> <math>\rightleftharpoons</math> [[dichloroarcyriaflavin A]] + 2 CO<sub>2</sub> + 6 H<sub>2</sub>O + 4 NAD<sup>+</sup>

RebP is an NAD-dependent [[cytochrome P450]] [[oxygenase]] that performs an aryl-aryl bond formation

== References ==
{{reflist}}

== External links ==
* {{MeshName|Dichloroarcyriaflavin+A+synthase}}

[[Category:EC 1.13.12]]