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{{Infobox enzyme
| Name = Premnaspirodiene oxygenase
| EC_number = 1.14.13.121
| CAS_number = 
| IUBMB_EC_number = 1/14/13/121
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Premnaspirodiene oxygenase''' ({{EC number|1.14.13.121}}, ''HPO'', ''Hyoscymus muticus premnaspirodiene oxygenase'') is an [[enzyme]] with system name ''(-)-vetispiradiene,NADPH:oxygen 2alpha-oxidoreductase''.<ref>{{cite journal | title = Functional characterization of premnaspirodiene oxygenase, a cytochrome ''P''<sub>450</sub> catalyzing regio- and stereo-specific hydroxylations of diverse  sesquiterpene substrates |author = Takahashi, S., Yeo, Y.S., Zhao, Y., O'Maille, P.E., Greenhagen, B.T., Noel, J.P., Coates, R.M. and Chappell, J. |journal = J. Biol. Chem. |year = 2007 |volume = 282 |pages = 31744–31754 |pmid = 17715131 |doi=10.1074/jbc.M703378200 |issue=43 |pmc=2695360}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: (-)-vetispiradiene + 2 NADPH + 2 H<sup>+</sup> + 2 O<sub>2</sub> <math>\rightleftharpoons</math> solavetivone + 2 NADP<sup>+</sup> + 3 H<sub>2</sub>O (overall reaction)
:(1a) (-)-vetispiradiene + NADPH + H<sup>+</sup> + O<sub>2</sub> <math>\rightleftharpoons</math> solavetivol + NADP<sup>+</sup> + H<sub>2</sub>O
:(1b) solavetivol + NADPH + H<sup>+</sup> + O<sub>2</sub> <math>\rightleftharpoons</math> solavetivone + NADP<sup>+</sup> + 2 H<sub>2</sub>O

Premnaspirodiene oxygenase [[heme]]-[[thiol]]ate protein (P-450).

== References ==
{{reflist}}

== External links ==
* {{MeshName|Premnaspirodiene+oxygenase}}

[[Category:EC 1.14.13]]