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{{enzyme
| Name = Choloyl-CoA hydrolase
| EC_number = 3.1.2.27
| CAS_number = 
| IUBMB_EC_number = 3/1/2/27
| GO_code = 
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''choloyl-CoA hydrolase''' ({{EC number|3.1.2.27}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:choloyl-CoA + H<sub>2</sub>O <math>\rightleftharpoons</math> cholate + CoA

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[choloyl-CoA]] and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[cholate]] and [[coenzyme A|CoA]].

This enzyme belongs to the family of [[hydrolase]]s, specifically those acting on [[thioester]] bonds.  The systematic name of this enzyme class is '''choloyl-CoA hydrolase'''. Other names in common use include '''PTE-2 (ambiguous)''', '''choloyl-coenzyme A thioesterase''', '''chenodeoxycholoyl-coenzyme A thioesterase''', and '''peroxisomal acyl-CoA thioesterase 2'''.  

==References==
{{reflist|1}}
* {{cite journal | author = Hunt MC, Solaas K, Kase BF, Alexson SE | date = 2002 | title = Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism | journal = J. Biol. Chem.  | volume = 277 | pages = 1128&ndash;38  | pmid = 11673457 | doi = 10.1074/jbc.M106458200 | issue = 2 }}
* {{cite journal | author = Solaas K, Sletta RJ, Soreide O, Kase BF | date = 2000 | title = Presence of choloyl- and chenodeoxycholoyl-coenzyme A thioesterase activity in human liver | journal = Scand. J. Clin. Lab. Invest.  | volume = 60 | pages = 91&ndash;102  | pmid = 10817395 | doi = 10.1080/00365510050184903 | issue = 2 }}
* {{cite journal | author = Russell DW | date = 2003 | title = The enzymes, regulation, and genetics of bile acid synthesis | journal = Annu. Rev. Biochem.  | volume = 72 | pages = 137&ndash;74  | pmid = 12543708 | doi = 10.1146/annurev.biochem.72.121801.161712 }}

{{hydrolase-stub}}

[[Category:EC 3.1.2]]
[[Category:Enzymes of unknown structure]]