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{{Infobox enzyme
| Name = D-xylose reductase
| EC_number = 1.1.1.307
| CAS_number = 
| IUBMB_EC_number = 1/1/1/307
| GO_code = 
| image = 
| width = 
| caption =
}}
'''D-xylose reductase''' ({{EC number|1.1.1.307}}, ''XylR'', ''XyrA'', ''msXR'', ''dsXR'', ''monospecific xylose reductase'', ''dual specific xylose reductase'', ''NAD(P)H-dependent xylose reductase'', ''xylose reductase'') is an [[enzyme]] with system name ''xylitol:NAD(P)<sup>+</sup> oxidoreductase''.<ref>{{cite journal | title = NAD(P)H-dependent aldose reductase from the xylose-assimilating yeast ''Candida tenuis''. Isolation, characterization and biochemical properties of  the enzyme |author = Neuhauser, W., Haltrich, D., Kulbe, K.D. and Nidetzky, B. |journal = Biochem. J. |year = 1997 |volume = 326 |pages = 683–692 |pmid = 9307017 | pmc = 1218722 | issue = Pt 3}}</ref><ref>{{cite journal | title = Multiple forms of xylose reductase in ''Candida intermedia'': comparison of their functional properties using quantitative structure-activity  relationships, steady-state kinetic analysis, and pH studies |author = Nidetzky, B., Bruggler, K., Kratzer, R. and Mayr, P. |journal = J. Agric. Food Chem. |year = 2003 |volume = 51 |pages = 7930–7935 |pmid = 14690376 | doi = 10.1021/jf034426j | issue = 27}}</ref><ref>{{cite journal | title = The activity of xylose reductase and xylitol dehydrogenase in yeasts |author = Iablochkova, E.N., Bolotnikova, O.I., Mikhailova, N.P., Nemova, N.N. and Ginak, A.I. |journal = Mikrobiologiia |year = 2003 |volume = 72 |pages = 466–469 |pmid = 14526534 | issue = 4}}</ref><ref>{{cite journal | title = Purification, crystallization and preliminary X-ray crystallographic analysis of xylose reductase from ''Candida tropicalis'' |author = Chen, L.C., Huang, S.C., Chuankhayan, P., Chen, C.D., Huang, Y.C., Jeyakanthan, J., Pang, H.F., Men, L.C., Chen, Y.C., Wang, Y.K., Liu, M.Y., Wu, T.K. and Chen, C.J. |journal = Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. |year = 2009 |volume = 65 |pages = 419–421 |pmid = 19342796 | doi = 10.1107/S1744309109008719 | issue = Pt 4 | pmc = 2664776}}</ref><ref>{{cite journal | title = Properties of the NAD(P)H-dependent xylose reductase from the xylose-fermenting yeast ''Pichia stipitis'' |author = Verduyn, C., Van Kleef, R., Frank, J., Schreuder, H., Van Dijken, J.P. and Scheffers, W.A. |journal = Biochem. J. |year = 1985 |volume = 226 |pages = 669–677 |pmid = 3921014 | issue = 3 | pmc = 1144764}}</ref><ref>{{cite journal | title = Xylose reductase from the thermophilic fungus Talaromyces emersonii: cloning and heterologous expression of the native gene (Texr) and a double mutant (TexrK271R + N273D) with altered coenzyme specificity |author = Fernandes, S., Tuohy, M.G. and Murray, P.G. |journal = J. Biosci. |year = 2009 |volume = 34 |pages = 881–890 |pmid = 20093741 | doi = 10.1007/s12038-009-0102-7 | issue = 6}}</ref><ref>{{cite journal | title = Cloning and characterization of the xyl1 gene, encoding an NADH-preferring xylose reductase from ''Candida parapsilosis'', and its functional expression  in ''Candida tropicalis'' |author = Lee, J.K., Koo, B.S. and Kim, S.Y. |journal = Appl. Environ. Microbiol. |year = 2003 |volume = 69 |pages = 6179–6188 |pmid = 14532079 | doi = 10.1128/AEM.69.10.6179-6188.2003 | issue = 10 | pmc = 201247}}</ref><ref>{{cite journal | title = Heterologous expression, purification, and characterization of a highly active xylose reductase from ''Neurospora crassa'' |author = Woodyer, R., Simurdiak, M., van der Donk, W.A. and Zhao, H. |journal = Appl. Environ. Microbiol. |year = 2005 |volume = 71 |pages = 1642–1647 |pmid = 15746370 | doi = 10.1128/AEM.71.3.1642-1647.2005 | issue = 3 | pmc = 1065158}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[xylitol]] + NAD(P)<sup>+</sup> <math>\rightleftharpoons</math> D-[[xylose]] + NAD(P)H + H<sup>+</sup>

Xylose reductase catalyses the initial reaction in the xylose utilization pathway, the NAD(P)H dependent reduction of xylose to xylitol.

== References ==
{{reflist}}

== External links ==
* {{MeshName|D-xylose+reductase}}

[[Category:EC 1.1.1]]