View source for DTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+)

{{Infobox enzyme
| Name = Glycerol-3-phosphate dehydrogenase
| EC_number = 1.1.5.3
| CAS_number = 9001-49-4
| IUBMB_EC_number = 1/1/5/3
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Glycerol-3-phosphate dehydrogenase''' ({{EC number|1.1.5.3}}, ''alpha-glycerophosphate dehydrogenase'', ''alpha-glycerophosphate dehydrogenase (acceptor)'', ''anaerobic glycerol-3-phosphate dehydrogenase'', ''DL-glycerol 3-phosphate oxidase (misleading)'', ''FAD-dependent glycerol-3-phosphate dehydrogenase'', ''FAD-dependent sn-glycerol-3-phosphate dehydrogenase'', ''FAD-GPDH'', ''FAD-linked glycerol 3-phosphate dehydrogenase'', ''FAD-linked L-glycerol-3-phosphate dehydrogenase'', ''flavin-linked glycerol-3-phosphate dehydrogenase'', ''flavoprotein-linked L-glycerol 3-phosphate dehydrogenase'', ''glycerol 3-phosphate cytochrome c reductase (misleading)'', ''glycerol phosphate dehydrogenase'', ''glycerol phosphate dehydrogenase (acceptor)'', ''glycerol phosphate dehydrogenase (FAD)'', ''glycerol-3-phosphate CoQ reductase'', ''glycerol-3-phosphate dehydrogenase (flavin-linked)'', ''glycerol-3-phosphate:CoQ reductase'', ''glycerophosphate dehydrogenase'', ''L-3-glycerophosphate-ubiquinone oxidoreductase'', ''L-glycerol-3-phosphate dehydrogenase (ambiguous)'', ''L-glycerophosphate dehydrogenase'', ''mGPD'', ''mitochondrial glycerol phosphate dehydrogenase'', ''NAD+-independent glycerol phosphate dehydrogenase'', ''pyridine nucleotide-independent L-glycerol 3-phosphate dehydrogenase'', ''sn-glycerol 3-phosphate oxidase (misleading)'', ''sn-glycerol-3-phosphate dehydrogenase'', ''sn-glycerol-3-phosphate:(acceptor) 2-oxidoreductase'', ''sn-glycerol-3-phosphate:acceptor 2-oxidoreductase'') is an [[enzyme]] with system name ''sn-glycerol 3-phosphate:quinone oxidoreductase''.<ref>{{cite journal | title = Studies on the mitochondrial &alpha;-glycerophosphate dehydrogenase. II. Extraction and partial purification of the dehydrogenase from pig brain |author = Ringler, R.L. |journal = J. Biol. Chem. |year = 1961 |volume = 236 |pages = 1192–1198 |pmid = 13741763}}</ref><ref>{{cite journal | title = Chemical and functional properties of the native and reconstituted forms of the membrane-bound, aerobic glycerol-3-phosphate dehydrogenase of  ''Escherichia coli'' |author = Schryvers, A., Lohmeier, E. and Weiner, J.H. |journal = J. Biol. Chem. |year = 1978 |volume = 253 |pages = 783–788 |pmid = 340460 |issue=3}}</ref><ref>{{cite journal | title = Calcium activation of mitochondrial glycerol phosphate dehydrogenase restudied |author = MacDonald, M.J. and Brown, L.J. |journal = Arch. Biochem. Biophys. |year = 1996 |volume = 326 |pages = 79–84 |pmid = 8579375 |doi=10.1006/abbi.1996.0049 |issue=1}}</ref><ref>{{cite journal | title = Steady-state kinetics of reduction of coenzyme Q analogs by glycerol-3-phosphate dehydrogenase in brown adipose tissue mitochondria |author = Rauchov&aacute;, H., Fato, R., Drahota, Z. and Lenaz, G. |journal = Arch. Biochem. Biophys. |year = 1997 |volume = 344 |pages = 235–241 |pmid = 9244403 |doi=10.1006/abbi.1997.0150 |issue=1}}</ref><ref>{{cite journal | title = Identification of a mitochondrial glycerol-3-phosphate dehydrogenase from ''Arabidopsis thaliana'': evidence for a mitochondrial glycerol-3-phosphate  shuttle in plants |author = Shen, W., Wei, Y., Dauk, M., Zheng, Z. and Zou, J. |journal = FEBS Lett. |year = 2003 |volume = 536 |pages = 92–96 |pmid = 12586344 |issue=1-3}}</ref><ref>{{cite journal | title = Aerobic ''sn''-glycerol-3-phosphate dehydrogenase from ''Escherichia coli'' binds to the cytoplasmic membrane through an amphipathic &alpha;-helix |author = Walz, A.C., Demel, R.A., de Kruijff, B. and Mutzel, R. |journal = Biochem. J. |year = 2002 |volume = 365 |pages = 471–479 |pmid = 11955283 |doi=10.1042/BJ20011853 |issue=Pt 2 |pmc=1222694}}</ref><ref>{{cite journal | title = The two isoenzymes for yeast NAD<sup>+</sup>-dependent glycerol 3-phosphate dehydrogenase encoded by GPD1 and GPD2 have distinct roles in  osmoadaptation and redox regulation |author = Ansell, R., Granath, K., Hohmann, S., Thevelein, J.M. and Adler, L. |journal = EMBO J. |year = 1997 |volume = 16 |pages = 2179–2187 |pmid = 9171333 |doi=10.1093/emboj/16.9.2179 |pmc=1169820}}</ref><ref>{{cite journal | title = The importance of the glycerol 3-phosphate shuttle during aerobic growth of ''Saccharomyces cerevisiae'' |author = Larsson, C., P&aring;hlman, I.L., Ansell, R., Rigoulet, M., Adler, L. and Gustafsson, L. |journal = Yeast |year = 1998 |volume = 14 |pages = 347–357 |pmid = 9559543 |doi=10.1002/(SICI)1097-0061(19980315)14:4&lt;347::AID-YEA226&gt;3.0.CO;2-9 |issue=4}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: sn-glycerol 3-phosphate + quinone <math>\rightleftharpoons</math> glycerone phosphate + quinol

This flavin-dependent dehydrogenase is a membrane enzyme. It participates in glycolysis, respiration and phospholipid biosynthesis.

== References ==
{{reflist}}

== External links ==
* {{MeshName|Glycerol-3-phosphate+dehydrogenase}}

[[Category:EC 1.1.5]]