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{{enzyme
| Name = Indole-3-glycerol-phosphate lyase
| EC_number = 4.1.2.8
| CAS_number = 
| IUBMB_EC_number = 4/1/2/8
| GO_code = 
| image = 
| width = 
| caption = 
}}

In [[enzymology]], an '''indole-3-glycerol-phosphate lyase''' ({{EC number|4.1.2.8}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate <math>\rightleftharpoons</math> indole + D-glyceraldehyde 3-phosphate

Hence, this enzyme has one [[substrate (biochemistry)|substrate]], [[(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate]], and two [[product (chemistry)|products]], [[indole]] and [[D-glyceraldehyde 3-phosphate]].

This enzyme belongs to the family of [[lyase]]s, specifically the aldehyde-lyases, which cleave carbon-carbon bonds.  The systematic name of this enzyme class is '''(1S,2R)-1-C-(indol-3-yl)glycerol-3-phosphate D-glyceraldehyde-3-phosphate-lyase (indole-forming)'''. Other names in common use include '''tryptophan synthase alpha''', '''TSA''', '''indoleglycerolphosphate aldolase''', '''indole glycerol phosphate hydrolase''', '''indole synthase''', '''indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase''', '''indole-3-glycerol phosphate lyase''', '''IGL''', '''BX1''', '''(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate''', and '''D-glyceraldehyde-3-phosphate-lyase'''.  This enzyme participates in [[benzoxazinone biosynthesis]].  

==References==
{{reflist|1}}
* {{cite journal | author = YANOFSKY C | date = 1956 | title = The enzymatic conversion of anthranilic acid to indole | journal = J. Biol. Chem.  | volume = 223 | pages = 171&ndash;84  | pmid = 13376586 | issue = 1 }}
* {{cite journal | author = SP, Simcox K and Gierl A | date = 1997 | title = Analysis of a chemical plant defense mechanism in grasses | journal = Science  | volume = 277 | pages = 696&ndash;699 | doi = 10.1126/science.277.5326.696 | pmid=9235894 | issue=5326}}
* {{cite journal | author = Frey M, Stettner C, Pare PW, Schmelz EA, Tumlinson JH, Gierl A | date = 2000 | title = An herbivore elicitor activates the gene for indole emission in maize | journal = Proc. Natl. Acad. Sci. U.S.A.  | volume = 97 | pages = 14801&ndash;6  | pmid = 11106389 | doi = 10.1073/pnas.260499897 | issue = 26 | pmc = 18999 }}
* {{cite journal | author = Melanson D, Chilton MD, Masters-Moore D, Chilton WS | date = 1997 | title = A deletion in an indole synthase gene is responsible for the DIMBOA-deficient phenotype of bxbx maize | journal = Proc. Natl. Acad. Sci. U.S.A.  | volume = 94 | pages = 13345&ndash;50  | pmid = 9371848 | doi = 10.1073/pnas.94.24.13345 | issue = 24 | pmc = 24311 }}

{{4.1-enzyme-stub}}

[[Category:EC 4.1.2]]
[[Category:Enzymes of unknown structure]]