View source for Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase

{{enzyme
| Name = glycoprotein 2-beta-D-xylosyltransferase
| EC_number = 2.4.2.38
| CAS_number = 141256-56-6
| IUBMB_EC_number = 2/4/2/38
| GO_code = 0050513
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''glycoprotein 2-beta-D-xylosyltransferase''' ({{EC number|2.4.2.38}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:UDP-D-xylose + N<sub>4</sub>-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N- acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D- mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D- glucosaminyl}asparagine <math>\rightleftharpoons</math> UDP + N<sub>4</sub>-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N- acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D- xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl- (1->4)-N-acetyl-beta-D-glucosaminyl}asparagine

The 5 [[substrate (biochemistry)|substrates]] of this enzyme are [[UDP-D-xylose]], [[N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-]], [[acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-]], [[mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-]], and [[glucosaminyl}asparagine]], whereas its 5 [[product (chemistry)|products]] are [[uridine diphosphate|UDP]], [[N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-]], [[acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]]-[[beta-D-]], [[xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-]], and [[(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine]].

This enzyme belongs to the family of [[glycosyltransferase]]s, specifically the pentosyltransferases.  The systematic name of this enzyme class is '''UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-a cetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-man nosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glu cosaminyl}asparagine) 2-beta-D-xylosyltransferase'''. Other names in common use include '''beta1,2-xylosyltransferase''', '''UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose''', '''of''', '''4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-''', '''acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-''', '''mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-''', and '''glucosaminyl}asparagine) 2-beta-D-xylosyltransferase'''.  This enzyme participates in [[glycan structures - biosynthesis 1]].

==References==
{{reflist|1}}
* {{cite journal | author = Zeng Y, Bannon G, Thomas VH, Rice K, Drake R, Elbein A | year = 1997 | title = Purification and specificity of beta1,2-xylosyltransferase, an enzyme that contributes to the allergenicity of some plant proteins | journal = J. Biol. Chem.  | volume = 272 | pages = 31340&ndash;7  | pmid = 9395463 | doi = 10.1074/jbc.272.50.31340 | issue = 50 }}
* {{cite journal | author = Steinkellner H | year = 2000 | title = Molecular cloning and functional expression of beta1, 2-xylosyltransferase cDNA from Arabidopsis thaliana | journal = FEBS. Lett.  | volume = 472 | pages = 105&ndash;8  | pmid = 10781814 | doi = 10.1016/S0014-5793(00)01443-5 | last2 = Mucha | first2 = J | last3 = Mach | first3 = L | last4 = Altmann | first4 = F | last5 = Wilson | first5 = IB | last6 = Glössl | first6 = J | last7 = Steinkellner | first7 = H | issue = 1 }}

[[Category:EC 2.4.2]]
[[Category:Enzymes of unknown structure]]


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