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{{Infobox enzyme
| Name = Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
| EC_number = 2.4.1.224
| CAS_number = 336193-98-7
| IUBMB_EC_number = 2/4/1/224
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase''' ({{EC number|2.4.1.224}}, ''alpha-N-acetylglucosaminyltransferase II glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N-acetylglucosaminyltransferase'') is an [[enzyme]] with system name ''UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase''.<ref>{{cite journal | title = Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode &alpha;1,4-<em>N</em>-acetylglucosaminyltransferases that likely are involved in heparan sulfate/heparin biosynthesis |author = Kim, B.T., Kitagawa, H., Tamura, J., Saito, T., Kusche-Gullberg, M., Lindahl, U. and Sugahara, K. |journal = Proc. Natl. Acad. Sci. USA |year = 2001 |volume = 98 |pages = 7176–7181 |pmid = 11390981 |doi=10.1073/pnas.131188498 |issue=13 |pmc=34642}}</ref><ref>{{cite journal | title = <em>rib-2</em>, a <em>Caenorhabditis elegans</em> homolog of the human tumor suppressor <em>EXT</em> genes encodes a novel &alpha;1,4-<em>N</em>-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate |author = Kitagawa, H., Egusa, N., Tamura, J.I., Kusche-Gullberg, M., Lindahl, U. and Sugahara, K. |journal = J. Biol. Chem. |year = 2001 |volume = 276 |pages = 4834–4838 |pmid = 11121397 |doi=10.1074/jbc.C000835200 |issue=7}}</ref><ref>{{cite journal | title = The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis |author = Senay, C., Lind, T., Muguruma, K., Tone, Y., Kitagawa, H., Sugahara, K., Lidholt, K., Lindahl, U. and Kusche-Gullberg, M. |journal = EMBO Rep. |year = 2000 |volume = 1 |pages = 282–286 |pmid = 11256613 |doi=10.1093/embo-reports/kvd045 |pmc=1083719}}</ref><ref>{{cite journal | title = The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate |author = Lind, T., Tufaro, F., McCormick, C., Lindahl, U. and Lidholt, K. |journal = J. Biol. Chem. |year = 1998 |volume = 273 |pages = 26265–26268 |pmid = 9756849 |doi=10.1074/jbc.273.41.26265}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[UDP-N-acetyl-D-glucosamine]] + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan <math>\rightleftharpoons</math> UDP + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan

This enzyme is involved in the biosynthesis of [[heparin]] and [[heparan sulfate]].

== References ==
{{reflist}}

== External links ==
* {{MeshName|Glucuronosyl-N-acetylglucosaminyl-proteoglycan+4-alpha-N-acetylglucosaminyltransferase}}

[[Category:EC 2.4.1]]