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{{Infobox enzyme
| Name = Dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase
| EC_number = 2.4.1.256
| CAS_number = 
| IUBMB_EC_number = 2/4/1/256
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase''' ({{EC number|2.4.1.256}}, ''ALG10'', ''Dol-P-Glc:Glc2Man9GlcNAc2-PP-Dol alpha-1,2-glucosyltransferase'') is an [[enzyme]] with system name ''dolichyl beta-D-glucosyl phosphate:D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 2-alpha-D-glucosyltransferase''.<ref>{{cite journal | title = The ALG10 locus of ''Saccharomyces cerevisiae'' encodes the &alpha;-1,2 glucosyltransferase of the endoplasmic reticulum: the terminal glucose of  the lipid-linked oligosaccharide is required for efficient N-linked  glycosylation |author = Burda, P. and Aebi, M. |journal = Glycobiology |year = 1998 |volume = 8 |pages = 455–462 |pmid = 9597543}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: dolichyl beta-D-glucosyl phosphate + D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol <math>\rightleftharpoons</math> D-Glc-alpha-(1->2)-D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + [[dolichyl phosphate]]

This [[eukaryotic]] enzyme performs the final step in the synthesis of the lipid-linked [[oligosaccharide]].

== References ==
{{reflist}}

== External links ==
* {{MeshName|Dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol+alpha-1,2-glucosyltransferase}}

[[Category:EC 2.4.1]]