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{{enzyme
| Name = manganese-transporting ATPase
| EC_number = 3.6.3.35
| CAS_number = 
| IUBMB_EC_number = 3/6/3/35
| GO_code = 0015410
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''manganese-transporting ATPase''' ({{EC number|3.6.3.35}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:ATP + H<sub>2</sub>O + Mn<sub>2</sub>+out <math>\rightleftharpoons</math> ADP + phosphate + Mn<sub>2</sub>+in

The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine triphosphate|ATP]], [[water|H<sub>2</sub>O]], and [[Manganese|Mn]]<sup>2+</sup>, whereas its 3 [[product (chemistry)|products]] are [[adenosine diphosphate|ADP]], [[phosphate]], and [[Manganese|Mn]]<sup>2+</sup>.

This enzyme belongs to the family of [[hydrolase]]s, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is '''ATP phosphohydrolase (manganese-importing)'''. This enzyme is also called '''ABC-type manganese permease complex'''.

==References==
{{reflist|1}}
* {{cite journal | author = Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH Jr | year = 1995 | title = Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases | journal = Res. Microbiol.  | volume = 146 | pages = 271&ndash;8  | pmid = 7569321 | issue = 4 | doi=10.1016/0923-2508(96)81050-3}}
* {{cite journal | author = Saier MH Jr | year = 1998 | title = Advances in Microbial Physiology Volume 40 | journal = Adv. Microb. Physiol.  | volume = 40 | pages = 81&ndash;136  | pmid = 9889977 | doi = 10.1016/S0065-2911(08)60130-7 | chapter = Molecular Phylogeny as a Basis for the Classification of Transport Proteins from Bacteria, Archaea and Eukarya | series = Advances in Microbial Physiology | isbn = 978-0-12-027740-7 }}
* {{cite journal | author = Novak R, Braun JS, Charpentier E, Tuomanen E | year = 1998 | title = Penicillin tolerance genes of Streptococcus pneumoniae: the ABC-type manganese permease complex Psa | journal = Mol. Microbiol.  | volume = 29 | pages = 1285&ndash;96  | pmid = 9767595 | doi = 10.1046/j.1365-2958.1998.01016.x | issue = 5 }}
* {{cite journal | author = Kolenbrander PE, Andersen RN, Baker RA, Jenkinson HF | year = 1998 | title = The adhesion-associated sca operon in Streptococcus gordonii encodes an inducible high-affinity ABC transporter for Mn2+ uptake | journal = J. Bacteriol.  | volume = 180 | pages = 290&ndash;5  | pmid = 9440518 | issue = 2 | pmc = 106884 }}

[[Category:EC 3.6.3]]
[[Category:Enzymes of unknown structure]]


{{hydrolase-stub}}