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{{enzyme
| Name = inositol tetrakisphosphate 1-kinase
| EC_number = 2.7.1.134
| CAS_number = 
| IUBMB_EC_number = 2/7/1/134
| GO_code = 0047325
| image = 
| width = 
| caption = 
}}
In [[enzymology]], an '''inositol-tetrakisphosphate 1-kinase''' ({{EC number|2.7.1.134}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate <math>\rightleftharpoons</math> ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine triphosphate|ATP]] and [[1D-myo-inositol 3,4,5,6-tetrakisphosphate]], whereas its two [[product (chemistry)|products]] are [[adenosine diphosphate|ADP]] and [[1D-myo-inositol 1,3,4,5,6-pentakisphosphate]].

This enzyme belongs to the family of [[transferase]]s, specifically those transferring phosphorus-containing groups ([[phosphotransferase]]s) with an alcohol group as acceptor.  The systematic name of this enzyme class is '''ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase'''. Other names in common use include '''1D-myo-inositol-tetrakisphosphate 1-kinase''', '''inositol-trisphosphate 6-kinase''', '''1D-myo-inositol-trisphosphate 6-kinase''', '''ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase''', '''inositol-trisphosphate 5-kinase''', '''1D-myo-inositol-trisphosphate 5-kinase''', and '''ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase'''.  This enzyme participates in [[inositol phosphate metabolism]] and [[phosphatidylinositol signaling system]].  

==Structural studies==

As of late 2007, 3 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|2ODT}}, {{PDB link|2Q7D}}, and {{PDB link|2QB5}}.

==References==
{{reflist|1}}
* {{cite journal | author = Stephens LR, Hawkins PT, Morris AJ, Downes PC | date = 1988 | title = L-myo-inositol 1,4,5,6-tetrakisphosphate (3-hydroxy)kinase | journal = Biochem. J.  | volume = 249 | pages = 283&ndash;92  | pmid = 2829850 | issue = 1 | pmc = 1148695 }}
* {{cite journal | author = Balla T, Guillemette G, Baukal AJ, Catt KJ | date = 1987 | title = Metabolism of inositol 1,3,4-trisphosphate to a new tetrakisphosphate isomer in angiotensin-stimulated adrenal glomerulosa cells | journal = J. Biol. Chem.  | volume = 262 | pages = 9952&ndash;5  | pmid = 3497156 | issue = 21 }}
* {{cite journal | author = Shears SB, Parry JB, Tang EK, Irvine RF, Michell RH, Kirk CJ | date = 1987 | title = Metabolism of D-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate | journal = Biochem. J.  | volume = 246 | pages = 139&ndash;47  | pmid = 2823793 | issue = 1 | pmc = 1148250 }}
* {{cite journal | author = Shears SB | date = 1989 | title = The pathway of myo-inositol 1,3,4-trisphosphate phosphorylation in liver. Identification of myo-inositol 1,3,4-trisphosphate 6-kinase, myo-inositol 1,3,4-trisphosphate 5-kinase, and myo-inositol 1,3,4,6-tetrakisphosphate 5-kinase | journal = J. Biol. Chem.  | volume = 264 | pages = 19879&ndash;86  | pmid = 2584198 | issue = 33 }}
* {{cite journal | author = Yang X, Shears SB | date = 2000 | title = Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase | journal = Biochem. J. 351 Pt  | volume = 3 | pages = 551&ndash;5  | pmid = 11042108 | pmc = 1221393 }}
* {{cite journal | author = Vogel G, Riley AM, Potter BV, Shears SB | date = 2002 | title = Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase | journal = Curr. Biol.  | volume = 12 | pages = 477&ndash;82  | pmid = 11909533 | doi = 10.1016/S0960-9822(02)00713-3 | issue = 6 }}

{{enzyme-stub}}

[[Category:EC 2.7.1]]
[[Category:Enzymes of known structure]]