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{{enzyme
| Name = lactosylceramide alpha-2,6-N-sialyltransferase
| EC_number = 2.4.99.11
| CAS_number = 55071-95-9
| IUBMB_EC_number = 2/4/99/11
| GO_code = 0047287
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''lactosylceramide alpha-2,6-N-sialyltransferase''' ({{EC number|2.4.99.11}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide <math>\rightleftharpoons</math> CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-beta-D- glucosylceramide

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[CMP-N-acetylneuraminate]] and [[beta-D-galactosyl-1,4-beta-D-glucosylceramide]], whereas its 3 [[product (chemistry)|products]] are [[cytidine monophosphate|CMP]], [[alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-beta-D-]], and [[glucosylceramide]].

This enzyme belongs to the family of [[transferase]]s, specifically those [[glycosyltransferase]]s that do not transfer hexosyl or pentosyl groups.  The systematic name of this enzyme class is '''CMP-N-acetylneuraminate:lactosylceramide alpha-2,6-N-acetylneuraminyltransferase'''. Other names in common use include '''cytidine monophosphoacetylneuraminate-lactosylceramide''', '''sialyltransferase''', '''CMP-acetylneuraminate-lactosylceramide-sialyltransferase''', '''CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase''', '''CMP-sialic acid:lactosylceramide sialyltransferase''', '''cytidine monophosphoacetylneuraminate-lactosylceramide''', and '''sialyltransferase'''.  

==References==
{{reflist|1}}
* {{cite journal | author = Albarracin I, Lassaga FE, Caputto R | date = 1988 | title = Purification and characterization of an endogenous inhibitor of the sialyltransferase CMP-N-acetylneuraminate: lactosylceramide alpha 2,6-N-acetylneuraminyltransferase (EC 2.4.99.-) | journal = Biochem. J.  | volume = 254 | pages = 559&ndash;65  | pmid = 2460092 | issue = 2 | pmc = 1135114 }}
* {{cite journal | author = Landa CA, Maccioni HJ, Arce A, Caputto R | date = 1977 | title = The biosynthesis of brain gangliosides. Separation of membranes with different ratios of ganglioside sialylating activity to gangliosides | journal = Biochem. J.  | volume = 168 | pages = 325&ndash;32  | pmid = 606237 | issue = 3 | pmc = 1183776 }}

{{enzyme-stub}}

[[Category:EC 2.4.99]]
[[Category:Enzymes of unknown structure]]