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{{Infobox enzyme
| Name = Malonyl CoA reductase (malonate semialdehyde-forming)
| EC_number = 1.2.1.75
| CAS_number = 
| IUBMB_EC_number = 1/2/1/75
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Malonyl CoA reductase (malonate semialdehyde-forming)''' ({{EC number|1.2.1.75}}, ''NADP-dependent malonyl CoA reductase'', ''malonyl CoA reductase (NADP)'') is an [[enzyme]] with system name ''malonate semialdehyde:NADP<sup>+</sup> oxidoreductase (malonate semialdehyde-forming)''.<ref>{{cite journal | title = Enzymes of a novel autotrophic CO<sub>2</sub> fixation pathway in the phototrophic bacterium ''Chloroflexus aurantiacus'', the 3-hydroxypropionate cycle |author = Strauss, G. and Fuchs, G. |journal = Eur. J. Biochem. |year = 1993 |volume = 215 |pages = 633–643 |pmid = 8354269 |doi=10.1111/j.1432-1033.1993.tb18074.x}}</ref><ref>{{cite journal | title = A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in ''Archaea'' |author = Berg, I.A., Kockelkorn, D., Buckel, W. and Fuchs, G. |journal = Science |year = 2007 |volume = 318 |pages = 1782–1786 |pmid = 18079405 |doi=10.1126/science.1149976}}</ref><ref>{{cite journal | title = Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal ''Metallosphaera'' and ''Sulfolobus'' spp |author = Alber, B., Olinger, M., Rieder, A., Kockelkorn, D., Jobst, B., Hugler, M. and Fuchs, G. |journal = J. Bacteriol. |year = 2006 |volume = 188 |pages = 8551–8559 |pmid = 17041055 |doi=10.1128/JB.00987-06 |issue=24 |pmc=1698253}}</ref><ref>{{cite journal | title = Malonyl-coenzyme A reductase from ''Chloroflexus aurantiacus'', a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO<sub>2</sub> fixation |author = Hugler, M., Menendez, C., Schagger, H. and Fuchs, G. |journal = J. Bacteriol. |year = 2002 |volume = 184 |pages = 2404–2410 |pmid = 11948153 |pmc=134993 |issue=9}}</ref> This enzyme [[catalysis|catalyse]] the following [[chemical reaction]]

: malonate semialdehyde + CoA + NADP<sup>+</sup> <math>\rightleftharpoons</math> malonyl-CoA + NADPH + H<sup>+</sup>

Requires Mg<sup>2+</sup>. Catalyses the reduction of malonyl-CoA to malonate semialdehyde.

== References ==
{{reflist}}

== External links ==
* {{MeshName|Malonyl+CoA+reductase+(malonate+semialdehyde-forming)}}

[[Category:EC 1.2.1]]