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{{Infobox enzyme
| Name = Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)
| EC_number = 2.5.1.83
| CAS_number = 
| IUBMB_EC_number = 2/5/1/83
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)''' ({{EC number|2.5.1.83}}, ''HexPS'', ''hexaprenyl pyrophosphate synthetase'', ''hexaprenyl diphosphate synthase'') is an [[enzyme]] with system name ''(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units)''.<ref>{{cite journal | title = Hexaprenyl pyrophosphate synthetase from ''Micrococcus luteus'' B-P 26. Separation of two essential components |author = Fujii, H., Koyama, T. and Ogura, K. |journal = J. Biol. Chem. |year = 1982 |volume = 257 |pages = 14610–14612 |pmid = 7174655 | issue = 24}}</ref><ref>{{cite journal | title = Molecular cloning, expression, and characterization of the genes encoding the two essential protein components of ''Micrococcus luteus'' B-P 26  hexaprenyl diphosphate synthase |author = Shimizu, N., Koyama, T. and Ogura, K. |journal = J. Bacteriol. |year = 1998 |volume = 180 |pages = 1578–1581 |pmid = 9515931 | issue = 6 | pmc = 107062}}</ref><ref>{{cite journal | title = Artificial substrates of medium-chain elongating enzymes, hexaprenyl- and heptaprenyl diphosphate synthases |author = Nagaki, M., Kimura, K., Kimura, H., Maki, Y., Goto, E., Nishino, T. and Koyama, T. |journal = Bioorg. Med. Chem. Lett. |year = 2001 |volume = 11 |pages = 2157–2159 |pmid = 11514159 | doi = 10.1016/S0960-894X(01)00391-2 | issue = 16}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: (2E,6E)-farnesyl diphosphate + 3 [[isopentenyl diphosphate]] <math>\rightleftharpoons</math> 3 [[diphosphate]] + all-trans-hexaprenyl diphosphate

The enzyme prefers [[farnesyl diphosphate]] to [[geranylgeranyl diphosphate]] as an [[allylic]] substrate.

== References ==
{{reflist}}

== External links ==
*{{MeshName|Hexaprenyl-diphosphate+synthase+((2E,6E)-farnesyl-diphosphate+specific)}}

[[Category:EC 2.5.1]]