View source for Malate dehydrogenase (NAD(P)+)

{{Infobox enzyme
| Name = 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
| EC_number = 1.1.1.312
| CAS_number = 
| IUBMB_EC_number = 1/1/1/312
| GO_code = 
| image = 
| width = 
| caption =
}}
'''2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase''' ({{EC number|1.1.1.312}}, ''2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase'', ''4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP<sup>+</sup> oxidoreductase'', ''alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase'', ''4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase'', ''LigC'', ''ProD'') is an [[enzyme]] with system name ''4-carboxy-2-hydroxymuconate semialdehyde hemiacetal:NADP<sup>+</sup> 2-oxidoreductase''.<ref>{{cite journal | title = Purification and properties of &alpha;-hydroxy-&gamma;-carboxymuconic &epsilon;-semialdehyde dehydrogenase |author = Maruyama, K., Ariga, N., Tsuda, M. and Deguchi, K. |journal = J. Biochem. (Tokyo) |year = 1978 |volume = 83 |pages = 1125–1134 |pmid = 26671 |issue=4}}</ref><ref>{{cite journal | title = Isolation and identification of the reaction product of &alpha;-hydroxy-&gamma;-carboxymuconic &epsilon;-semialdehyde dehydrogenase |author = Maruyama, K. |journal = J. Biochem. |year = 1979 |volume = 86 |pages = 1671–1677 |pmid = 528534 |issue=6}}</ref><ref>{{cite journal | title = Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase |author = Maruyama, K. |journal = J. Biochem. (Tokyo) |year = 1983 |volume = 93 |pages = 557–565 |pmid = 6841353 |issue=2}}</ref><ref>{{cite journal | title = Genetic and biochemical characterization of 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase and its role in the protocatechuate 4,5-cleavage pathway in ''Sphingomonas paucimobilis'' SYK-6 |author = Masai, E., Momose, K., Hara, H., Nishikawa, S., Katayama, Y. and Fukuda, M. |journal = J. Bacteriol. |year = 2000 |volume = 182 |pages = 6651–6658 |pmid = 11073908 |issue=23 |pmc=111406}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP<sup>+</sup> <math>\rightleftharpoons</math> 2-oxo-2H-pyran-4,6-dicarboxylate + NADPH + H<sup>+</sup>

Unsubstituted aliphatic or aromatic [[aldehydes]] or [[glucose]] cannot serve as [[substrate (biochemistry)|substrate]] of this enzyme.

== References ==
{{reflist}}

== External links ==
* {{MeshName|2-hydroxy-4-carboxymuconate+semialdehyde+hemiacetal+dehydrogenase}}

[[Category:EC 1.1.1]]