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{{enzyme
| Name = palmitoyl-CoA hydrolase
| EC_number = 3.1.2.2
| CAS_number = 9025-87-0
| IUBMB_EC_number = 3/1/2/2
| GO_code = 0016290
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''palmitoyl-CoA hydrolase''' ({{EC number|3.1.2.2}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:palmitoyl-CoA + H<sub>2</sub>O <math>\rightleftharpoons</math> CoA + palmitate

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[palmitoyl-CoA]] and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[coenzyme A|CoA]] and [[palmitate]].

This enzyme belongs to the family of [[hydrolase]]s, specifically those acting on [[thioester]] bonds.  The systematic name of this enzyme class is '''palmitoyl-CoA hydrolase'''. Other names in common use include '''long-chain fatty-acyl-CoA hydrolase''', '''palmitoyl coenzyme A hydrolase''', '''palmitoyl thioesterase''', '''palmitoyl coenzyme A hydrolase''', '''palmitoyl-CoA deacylase''', '''palmityl thioesterase''', '''palmityl-CoA deacylase''', '''fatty acyl thioesterase I''', and '''palmityl thioesterase I'''.  

==Structural studies==

As of late 2007, 3 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1TBU}}, {{PDB link|2Q2B}}, and {{PDB link|2QQ2}}.

==References==
{{reflist|1}}
* {{cite journal | author = Barnes EM Jr, Wakil SJ | date = 1968 | title = Studies on the mechanism of fatty acid synthesis. XIX. Preparation and general properties of palmityl thioesterase | journal = J. Biol. Chem.  | volume = 243 | pages = 2955&ndash;62  | pmid = 4871199 | issue = 11 }}
* {{cite journal | author = Berge RK, Farstad M | date = 1981 | title = Long-chain fatty acyl-CoA hydrolase from rat liver mitochondria | journal = Methods. Enzymol. 71 Pt  | volume = C | pages = 234&ndash;42  | pmid = 6116156 }}
* {{cite journal | doi = 10.1111/j.1432-1033.1981.tb06356.x | author = Miyazawa S, Furuta S, Hashimoto T | date = 1981 | title = Induction of a novel long-chain acyl-CoA hydrolase in rat liver by administration of peroxisome proliferators | journal = Eur. J. Biochem.  | volume = 117 | pages = 425&ndash;30  | pmid = 6115749 | issue = 2 }}
* {{cite journal | author = Srere PA, Seubert W and Lynen F | date = 1959 | title = Palmityl coenzyme A deacylase | journal = Biochim. Biophys. Acta  | volume = 33 | pages = 313&ndash;319 | doi = 10.1016/0006-3002(59)90118-0 | pmid=13670899 | issue = 2}}
* {{cite journal | author = Yabusaki KK and Ballou CE | date = 1981 | title = Long-chain fatty acyl-CoA thioesterases from Mycobacterium smegmatis | journal = Methods Enzymol.  | volume = 71 | pages = 242&ndash;246 | doi = 10.1016/0076-6879(81)71031-0 | series = Methods in Enzymology | isbn = 978-0-12-181971-2 }}

{{hydrolase-stub}}

[[Category:EC 3.1.2]]
[[Category:Enzymes of known structure]]