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{{Infobox enzyme
| Name = GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase
| EC_number = 2.4.1.257
| CAS_number = 
| IUBMB_EC_number = 2/4/1/257
| GO_code = 
| image = 
| width = 
| caption =
}}
'''GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase''' ({{EC number|2.4.1.257}}, ''GDP-Man:Man2GlcNAc2-PP-Dol alpha-1,6-mannosyltransferase'', ''Alg2 mannosyltransferase'', ''[[ALG2|ALG2 (gene)]]'', ''GDP-Man:Man1GlcNAc2-PP-dolichol mannosyltransferase'') is an [[enzyme]] with system name ''GDP-D-mannose:D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-6-mannosyltransferase''.<ref>{{cite journal | title = Biochemical characterization and membrane topology of Alg2 from ''Saccharomyces cerevisiae'' as a bifunctional &alpha;1,3- and  1,6-mannosyltransferase involved in lipid-linked oligosaccharide  biosynthesis |author = Kampf, M., Absmanner, B., Schwarz, M. and Lehle, L. |journal = J. Biol. Chem. |year = 2009 |volume = 284 |pages = 11900–11912 |pmid = 19282279}}</ref><ref>{{cite journal | title = ''In vitro'' evidence for the dual function of Alg2 and Alg11: essential mannosyltransferases in N-linked glycoprotein biosynthesis |author = O'Reilly, M.K., Zhang, G. and Imperiali, B. |journal = Biochemistry |year = 2006 |volume = 45 |pages = 9593–9603 |pmid = 16878994}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[GDP-D-mannose]] + D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol <math>\rightleftharpoons</math> GDP + D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol

The biosynthesis of asparagine-linked [[glycoprotein]]s utilizes a dolichyl diphosphate-linked [[glycosyl]] donor.

== References ==
{{reflist}}

== External links ==
* {{MeshName|GDP-Man:Man2GlcNAc2-PP-dolichol+alpha-1,6-mannosyltransferase}}

[[Category:EC 2.4.1]]