View source for NGC 4845

{{Infobox enzyme
| Name = Diadenosine hexaphosphate hydrolase (ATP-forming)
| EC_number = 3.6.1.61
| CAS_number = 
| IUBMB_EC_number = 3/6/1/61
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Diadenosine hexaphosphate hydrolase (ATP-forming)''' ({{EC number|3.6.1.61}}, ''Ndx1'') is an [[enzyme]] with system name ''P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (ATP-forming)''.<ref>{{cite journal | title = The Nudix hydrolase Ndx1 from <em>Thermus thermophilus</em> HB8 is a diadenosine hexaphosphate hydrolase with a novel activity |author = Iwai, T., Kuramitsu, S. and Masui, R. |journal = J. Biol. Chem. |year = 2004 |volume = 279 |pages = 21732–21739 |pmid = 15024014}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: (1) P1,P6-bis(5'-adenosyl)hexaphosphate + H<sub>2</sub>O <math>\rightleftharpoons</math> 2 ATP 
: (2) P1,P5-bis(5'-adenosyl)pentaphosphate + H<sub>2</sub>O <math>\rightleftharpoons</math> ATP + ADP
: (3) P1,P4-bis(5'-adenosyl)tetraphosphate + H<sub>2</sub>O <math>\rightleftharpoons</math> ATP + AMP

The enzyme requires the presence of the divalent cations (Mn<sup>2+</sup>, Mg<sup>2+</sup>, Zn<sup>2+</sup>, and Co<sup>2+</sup>). 

== References ==
{{reflist}}

== External links ==
* {{MeshName|Diadenosine+hexaphosphate+hydrolase+(ATP-forming)}}

[[Category:EC 3.6.1]]